IBM researchers assembled a simulated mouse cortical hemisphere on one of the smaller BlueGene/L supercomputers. They then ran the simulation — at 10s of computer processing equal to 1s of brain function.
2008-03-04: Blue Brain

the brain has 100b neurons and 1t synapses. So they need to scale up the neurons by 10m and the synapses by 33K. By 2017, there should be a single whole brain simulation. Personalized whole brain simulation would follow by 2027-2037.

Blue Brain scientists are confident that, at some point in the next few years, they will be able to start simulating an entire brain.

2008-10-29: The scale needed

There are petaflop supercomputers now so if such a system were dedicated to brain emulation a system 10x larger than the rat brain could be simulated.

2014-03-14: A fun monte carlo simulation of when whole brain emulation will become feasible:

50% chance for WBE (if it ever arrives) before 2059, with the 25th % in 2047 and the 75th % in 2074. WBE before 2030 looks very unlikely and only 10% likely before 2040

2015-09-11: Ethics of brain simulations

What I hope happens is that computational neuroscientists think a bit about the issue of suffering in their simulations rather than slip into the comfortable “It is just a simulation, it cannot feel anything” mode of thinking by default.

It is easy to tell oneself that simulations do not matter because not only do we know how they work when we make them (giving us the illusion that we actually know everything there is to know about the system – obviously not true since we at least need to run them to see what happens), but institutionally it is easier to regard them as non-problems in terms of workload, conflicts and complexity (let’s not rock the boat at the planning meeting, right?) And once something is in the “does not matter morally” category it becomes painful to move it out of it – many will now be motivated to keep it there.

2021-06-18: Towards the mouse brain connectome

A connectomic study of a petascale fragment of human cerebral cortex”, Shapson-Coe et al 2021 (“…This “digital tissue” is a ~660K× scale up of an earlier saturated reconstruction from a small region of mouse cortex, published in 2015 (Kasthuri et al 2015). Although this scaleup was difficult, it was not 100000x more difficult and took about the same amount of time as the previous data set (~4 years)…The rapid improvements over the past few years…argues that analyzing volumes that are even 3 orders of magnitude larger, such as an exascale whole mouse brain connectome, will likely be in reach within 10 years.”

2023-08-31: Human Brain Project retrospective

It took 10 years, 500 scientists and €600m, and now the Human Brain Project — one of the biggest research endeavors ever funded by the European Union — is coming to an end. Its audacious goal was to understand the human brain by modelling it in a computer.

During its run, scientists under the umbrella of the Human Brain Project (HBP) have published 1000s of papers and made significant strides in neuroscience, such as creating detailed 3D maps of at least 200 brain regions, developing brain implants to treat blindness and using supercomputers to model functions such as memory and consciousness and to advance treatments for various brain conditions. The project did not achieve its goal of simulating the whole human brain — an aim that many scientists regarded as far-fetched in the first place. It changed direction several times, and its scientific output became “fragmented and mosaic-like”.