Unlike most diet pills on the market, this new pill, called fexaramine, doesn’t dissolve into the blood like appetite suppressants or caffeine-based diet drugs, but remains in the intestines, causing fewer side effects. “It sends out the same signals that normally happen when you eat a lot of food, so the body starts clearing out space to store it. But there are no calories and no change in appetite.” Evans’ laboratory has spent 20 years studying the farensoid X receptor (FXR), a protein that plays a role in how the body releases bile acids from the liver, digests food and stores fats and sugars. The human body turns on FXR at the beginning of a meal, to prepare for an influx of food. FXR not only triggers the release of bile acids for digestion, but also changes blood sugar levels and causes the body to burn some fats in preparation for the incoming meal.
Tag: science
Free diving
Water had some powerful, unknown capacity to slow humans’ hearts, and the blood in their bodies began flooding away from their limbs and toward their vital organs. He’d seen the same thing happen in deep-diving seals decades earlier; by shunting blood away from less important areas of the body, the seals were able to keep organs like the brain and heart oxygenated longer, extending the amount of time they could stay submerged. Immersion in water triggered the same mechanism in humans.
Largest cave city
just in time for my trip to cappadocia in 1 week…
A 5 ka underground city thought to be the largest in the world has been discovered in central Turkey. The subterranean settlement was discovered in the Nevşehir province of Turkey’s Central Anatolia region, in the historical area of Cappadocia.
Exolife within 20 years?
my money is on discovery of exolife within 20 years.
the discovery of extraterrestrial life is the defining moment in our lifetime. It will define our civilization
Mother of the Sea
In 1948, with Tokyo still largely in ruins and the reins of government still in the hands of an occupying army, the nori harvest completely failed. And it kept failing. No one knew why. Years and decades and a world war passed and Kathleen discovered something that no one suspected: Porphyra and another seaweed called Conchocelis rosea weren’t actually 2 different organisms. They were actually 2 different phases of nori’s lifecycle. Conchocelis rosea was a tiny spore-like thing that clung to tiny particles of seashell adrift in the water. The shell fragments were essentially life preservers for the nori-spores, which would otherwise sink to the bottom and be swallowed by the sediments. The nori fishers didn’t know that their harvest was dependent on another harvest, that of the shellfish along the same shores, and the shoals of discarded shells. The nori fishers of Ariake Bay, the producers of over half of Japan’s nori harvest, raised their small shrine to Kathleen. This coming April, they will mark the 51st anniversary of their small festival celebrating a woman that they never met, but whom they call “the mother of the sea.”
Centromeres are tricky
The scientists decided to return to the human genome and search for K111. They isolated DNA from their HIV patients, as well as from healthy people. Remarkably, the scientists didn’t find just 1 copy of K111 in each of their subject’s genomes, as is the case in chimps. The more the scientists looked, the more variants they found. Some K111 viruses were fairly intact, while others were vestiges. The scientists found over 100 copies of the virus in the human genome, scattered across 15 chromosomes.
This finding suggests that between 6 ma and 800 ka ago, K111 was duplicated a few times at a fairly slow pace. It’s possible that Markowitz and his colleagues missed some other copies because the reconstruction of those ancient genomes wasn’t quite accurate enough for their search. But even if we generously assumed that Neanderthals and Denisovans had 20 K111 viruses apiece, that’s still a small fraction of the 100 or more copies of K111 the scientists found in the human genome. It was only later, in the past 800 ka, that K111 started proliferating at a faster pace.1 reason that K111 has gone overlooked till now is that it found a good place to hide–the center of chromosomes. This region, called the centromere, is a genomic Bermuda Triangle. It’s loaded with lots of short, repetitive stretches of DNA. When scientists reconstruct the sequence of a genome, they break DNA down into many overlapping segments, which they then try to rebuild based on overlapping similarities. Centromere DNA is so similar to itself that it’s easy to line up fragments in many different arrangements. As a result, centromeres make up much of the last 5% of the human genome that has yet to be mapped.
Many Things Can Be Enzymes
Proteins can clearly do a terrific job, but is that because they’re clearly the best choice, or just the one that evolutionary biochemistry landed on? Can enzyme-like catalysts be made from chemically more robust scaffolds? Maybe. The authors describe several new “synthetic generic polymers”, with new and completely unnatural carbohydrate backbones, and show that these, too, can fold into catalytic species.
500 ka art
a long time before modern humans

A zigzag engraving on a shell from Indonesia is the oldest abstract marking ever found. But what is most surprising about the 500 ka doodle is its likely creator — the human ancestor Homo erectus.
Antikythera Mechanism

By examining the structure of the gears, the numbers of teeth, how they interact with each other, and the inscriptions, the AMRP confirmed that the device was an incredibly detailed astronomical calendar that could predict eclipses, calculate the dates of the Olympics, the positions of the sun, moon and planets in the solar system and more. There is nothing else like it known from antiquity, and no other mechanical device would even come close to its complexity until the Middle Ages. “It was not a research tool, something that an astronomer would use to do computations, or even an astrologer to do prognostications, but something that you would use to teach about the cosmos and our place in the cosmos. It’s like a textbook of astronomy as it was understood then, which connected the movements of the sky and the planets with the lives of the ancient Greeks and their environment.” It is pure luck that we fished this thing out of the Mediterranean in 1901. The alternative possibility is that antiquity had many more such exotic devices. We don’t have a very good idea of what antiquity was like.
2022-09-18: Reflections on the mechanism
WHETHER OR NOT sphaerae technology survived until the Renaissance remains unclear. I am inclined to follow Price, who believed it did, but a case can also be made for loss and reinvention. The technology might have been suppressed for religious reasons in later Roman days—certainly its suppression would only have been hastened if the sphaerae were associated with astrology. All that is known is that the technology persisted in Europe until at least 500 CE, and elements seem to have been reintroduced later through the Arabic world.
It is clear that Renaissance scholars knew the Greeks had made mechanical astronomical displays. This is attested, for example, by Giovanni de Dondi, who constructed an elaborate astronomical clock in approximately 1364 CE by Kepler in his letters around 1605 CE and in the writings of Conrad Dasypodius, who designed the Strasbourg astronomical clock around 1571–74 CE.
Given that the Greeks could build the Antikythera mechanism, a common question is what other devices they might have created. Some aspects of the technology can be seen in surviving medical instruments, including small-bore tubes and worm gears. Although the Greeks had elementary lathes, files, and bronze-casting ability, the limited accuracy achieved in the manufacture of gears may explain why there is no evidence of calculators for financial or surveying use. Another deterrent to calculators being designed may have been the ready availability of labor skilled in the abacus and other basic counting devices.
It was the lack of escapement technology that prevented the development of clocks, although some wheelwork was apparently used in clepsydrae. The use of large and crude wooden lantern gears continued in mills and other applications, but further development of practical mechanisms using small metal gears seems to have stalled. In explaining the lack of a classical industrial revolution and the emergence of precision manufacturing technology, many other considerations also come into play, in particular the abundance of slave and other labor, as well as the nature of pre-gunpowder military weapons.
Crazymeds
amazing that some enterprising soul managed to put together such a good site.
It’s excellent because it gives mostly accurate and readable descriptions of the costs and benefits of every psychiatric medication. It has a laser-like focus on what patients will actually want to know and was clearly written by someone with an encyclopedic knowledge of every treatment’s strengths and potential pitfalls.
This is important because the standard psychiatric response to someone who wants to know about a medication (when it’s not “shut up and trust me”) is to print out an information sheet from somewhere like drugs.com or webmd.com. These sites at worst just copy paste the FDA drug information sheet, and at best list off side effects in a rote and irrelevant way that only a robot could love.