a software system which produces and maintains automatic annotation on selected eukaryotic genomes
Tag: science
Distributed annotation system
A client-server system in which a single client integrates information from multiple servers. It allows a single machine to gather up genome annotation information from multiple distant web sites, collate the information, and display it to the user
Scientist Belief
science is fundamentally not about beliefs, it’s about results. Beliefs are relevant mostly as the heuristics that lead to results. So for example, it matters that David Deutsch believes the many-worlds interpretation because that’s what led him to quantum computing. It matters that Ed Witten believes string theory because that’s what led him to … well, all the mindblowing stuff it led him to. My beef with quantum computing skeptics has never been that their beliefs are false; rather, it’s that their beliefs almost never seem to lead them to new results.
on the silliness of asking scientists about their beliefs
Mapping Science
this looks totally awesome
2007-03-20:
i have this one in my office
Fusion
Inertial electrostatic confinement fusion provides a potential breakthrough in designing and implementing practical fusion power plants. This is a $5T / year market.
2007-04-27: inertial confinement is a lot more promising than magnetic confinement. Plus 1000x cheaper to build. This is very very exciting (and a $5t/ year market).
2008-01-15: Fusion power grows more quickly than Moore’s law. It has increased by a factor of 10000 in the last 30 years, and another factor of 6 is required for a power plant. ITER will be 500MW, 10x over the energy threshold.

2011-08-03: Mark Suppes:
I do believe this is the WORLD’S FIRST AMATEUR POLYWELL!!!
Science. It works, bitches. Mark Suppes is one of my heroes. He lives in Brooklyn. His hobby: building his own bussard fusion reactor. He will very likely fail, but what if he succeeds? Here is a nice article on him. If you are behind in your fusion terminology, bussard reactors are an alternative design that doesn’t require 10s of billions to get if off the ground. The best introduction is this tech talk:
2014-04-12: Since the big science / consortium approach hasn’t worked so far, maybe a macgyver approach will.
Ivanov’s story is just one example of the serendipity involved in this small Canadian company’s rise to the forefront of a worldwide race to harness nuclear fusion, a race that has been going on fitfully, consuming $10Bs, for more than 50 years. (All existing reactors operate using nuclear fission, rather than fusion, which is a very different process.) Started in 2002 by a successful corporate scientist in the throes of a midlife crisis, General Fusion has already outlasted past private-sector attempts to commercialize fusion energy. Instead of petering out, it’s garnered the attention and respect of a small but growing cadre of scientists, energy executives and adventurous investors around the world.
2016-08-15: Towards commercial fusion
If LPP is successful with their research and then successful with commercialization they will achieve commercial nuclear fusion at the cost of $400K-1M for a 5 megawatt generator that would produce power for about 0.3 cents per kwh instead of 6 cents per kwh for coal and natural gas. It would be a game changer. Their monthly reports have shown that there are many technical, material and theoretical challenges. LPP has shown a lot of grit and ingenuity to overcome challenges.
2016-11-04: Longer plasma
The Experimental Advanced Superconducting Tokamak (EAST) in Heifi, China was able to sustain plasma in the H-mode confinement regime for 102 seconds.
2019-02-17: Fusion Projects Use Misleading Power Terms
ITER has spent over $14B so far and will only reach some level of plasma energy gain for a few minutes at a time if everything works as planned. The condition of Q = 1, when the power being released by the fusion reactions is equal to the required heating power is called breakeven or scientific breakeven. Plasma breakeven can be 100x away from what is needed for a practical reactor.
As explained by Sabine Hossenfelder:
The Q-plasma also doesn’t take into account that if you want to operate a power plant, the heat that is created by the plasma would still have to be converted into electric energy, and that can only be done with a limited efficiency, optimistically maybe 50%. As a consequence, the Q total is much lower than the Q plasma. If you didn’t know this, you’re not alone. I didn’t know this until a few years ago either. How can such a confusion even happen? I mean, this isn’t rocket science. The total energy that goes into the reactor is more than the energy that goes into the plasma. And yet, science writers and journalists constantly get this wrong. They get the most basic fact wrong on a matter that affects 10s of billions of research funding. The plan is that ITER will generate 500 MegaWatts of fusion power in heat. If we assume a 50% efficiency for converting this heat into electricity, ITER will produce about 250 MegaWatts of electric power. That gives us a Q total of about 0.57. That’s 6% of the normally stated Q plasma of 10. Even optimistically, ITER will still consume 2x the power it generates. What’s with the earlier claim of a Q of 0.67 for the JET experiment? Same thing.
2019-06-27: Commonwealth Fusion Systems

The Reactor Core of Commonwealth Fusion Systems. This Tokamak plasma fusion ring supports the steepest temperature gradient in the solar system (1 million degrees to room temp within 2mm)!
2020-10-01: Venture capital is entering fusion
This third party analysis verifies our investment thesis; tokamak fusion is an engineering project, not a science project. If they can build it, the scientific community agrees on the performance that will result.
2022-05-24: An unwelcome bottleneck, tritium.
The tritium used in fusion experiments like ITER, and the smaller JET tokamak in the UK, comes from a very specific type of nuclear fission reactor called a heavy-water moderated reactor. But many of these reactors are reaching the end of their working life, and there are fewer than 30 left in operation worldwide. 20 in Canada, 4 in South Korea, and 2 in Romania, each producing about 100 grams of tritium a year. But now, with the help of AI-controlled magnets to help confine the fusion reaction, and advances in materials science, some companies are exploring alternatives. TAE Technologies is attempting to build a fusion reactor that uses hydrogen and boron, which it says will be a cleaner and more practical alternative to D-T fusion. It’s aiming to reach a net energy gain—where a fusion reaction creates more power than it consumes—by 2025. Boron can be extracted from seawater by the metric ton, and it has the added benefit of not irradiating the machine as D-T fusion does. It’s a more commercially viable route to scalable fusion power. But the mainstream fusion community is still pinning its hopes on ITER, despite the potential supply problems for its key fuel. “Fusion is really, really difficult, and anything other than deuterium-tritium is going to be 100x more difficult, 100 years from now maybe we can talk about something else.”
International Chemical Identifier
a standard way to identify chemical compounds. the 21th century version of standard nomenclature
Jason Rennie
recommendations / machine learning guy (now working for phil)
Enceladus

Particles spewed from Saturn’s moon Enceladus are sandblasting neighboring moons, leaving them sparklingly bright
2008-03-25: Life on Enceladus?
Could microbial life exist inside Enceladus, where no sunlight reaches, photosynthesis is impossible and no oxygen is available? The answer appears to be, yes, it could be possible.
I invite you to imagine the day when we might journey to the saturnian system and visit the Enceladus interplanetary geiser park, just because we can.
2008-10-24: Cassini pictures 
Saturn’s tiny, icy moon Enceladus has recently been visited by NASA’s Cassini orbiter on several very close approaches – once coming within a mere 25 kilometers of the surface. Scientists are learning a great deal about this curious little moon. Only 500 kilometers wide, it is very active, emitting internal heat, churning its surface, and – through cryovolcanism – ejecting masses of microscopic ice particles into Saturnian orbit. Cassini has been orbiting Saturn for over 4 years now, and has provided some amazing views of tiny Enceladus, some collected here.
2022-11-11: Phosphorus predicted
Team members performed thermodynamic and kinetic modeling that simulates the geochemistry of phosphorus based on insights from Cassini about the ocean-seafloor system on Enceladus. They developed the most detailed geochemical model to date of how seafloor minerals dissolve into Enceladus’s ocean and predicted that phosphate minerals would be unusually soluble there.
“The underlying geochemistry has an elegant simplicity that makes the presence of dissolved phosphorus inevitable, reaching levels close to or even higher than those in modern Earth seawater. What this means for astrobiology is that we can be more confident than before that the ocean of Enceladus is habitable.”

Composite stability
In an advance that could lead to composite materials with virtually limitless performance capabilities, a scientist has dispelled a 50-year-old theoretical notion that composite materials must be made only of “stable” individual materials to be stable overall.
Gelli Baff
Gelli baff turns bath time into playtime! Simply run your bath 5 cm deep, add gelli baff to and watch in amazement as your boring bath water magically turns into a fun, thick goo.
hmm. disturbing but cool.