Tag: medicine

Malaria vaccine

Delays for malaria vaccine. First european approval, then WHO approval, then per-country approval in Africa. No wonder we can’t have nice things with that much redundancy.
2021-04-24: Malaria Vaccine 77% effective

A year-long trial of R21 in Burkina Faso has shown 77% efficacy, which is by far the record, and which opens the way to potentially relieving a nearly incalculable burden of disease and human suffering. This is definitely the best malaria vaccine candidate the world has yet seen, and that is unequivocal good news. Congratulations and thanks to the widespread group of researchers who have made this possible – and especially, thanks to 450 infants and toddlers in central Burkina Faso and to their parents. You have done the world a great service.

2023-07-03: Many vaccines are in development, with different approaches.

Most vaccines aim to reduce malaria deaths and illness. But to eradicate malaria altogether, scientists will also have to find a way to stop transmission. Sporozoite- and merozoite-targeting vaccines could help to reduce transmission by preventing infections or reducing the number of parasites in the blood. Duffy, however, is working on an altogether different vaccine that makes transmission its main aim — one that can destroy the malaria parasite inside the mosquito.
Inside people, a small subset of merozoites differentiate into male and female gametocytes, which the parasite needs to complete the sexual stage of its life cycle. When a mosquito feeds on an infected person, it ingests red blood cells that contain the parasites’ gametocytes. These gametocytes emerge as gametes in the mosquito’s gut, mate, and eventually give rise to fresh sporozoites ready to infect the next person.
The idea behind Duffy’s vaccine is to take out the gametes by stimulating the human immune system to generate antibodies against a protein called Pfs230 that gametes display on their surface. A feeding mosquito will then take up not just the gametocytes, but also those antibodies. When gametes emerge from red blood cells in the mosquito’s gut, the theory goes, the antibodies will be there to destroy them before they can complete their development

Kazakhstan Sleeping Villages

tl;dr: no known cause

Radiation. Government conspiracy. Mass hysteria. There are plenty of theories as to why the residents of a tiny Kazakh mining region keep falling asleep for days at a time, but no answers. Deputy Prime Minister Berdibek Saparbaev announced that the mystery of the sleeping sickness had been solved: It was the specific combination of reduced levels of oxygen and heightened levels of carbon monoxide and hydrocarbons. But as usual, rumors overshadowed reality. “The real moment is that we came to the conclusion that there are natural processes that lead to the combination of these kinds of factors and that specifically this combination of factors could give this effect. I can’t say for certain now. Our assumption is that all 3 components must coincide. When all 3 exist, that’s when people will start falling and sleeping again.” He had searched for similar cases in scientific literature, but so far had found nothing. He suggested the illness would return in September when people started to heat their homes.

Biosimilars

Unlike the more common small-molecule drugs, biologics generally exhibit high molecular complexity, and may be quite sensitive to changes in manufacturing processes. Follow-on manufacturers do not have access to the originator’s molecular clone and original cell bank, nor to the exact fermentation and purification process, nor to the active drug substance. They do have access to the commercialized innovator product. Various factors, such as safety, pricing, manufacturing, entry barriers, physician acceptance, and marketing, will make the biosimilar market develop different from the generic market. The high cost to enter the market and the size of the biologic drug market make entry attractive but risky.

A prion love story

i think this would make for a great movie with a science-literate plot:

Results showed she had the defective gene. Sonia and Eric hesitated briefly, and then decided to make it their life’s work to find a cure for Sonia before she got sick. They have 25 years to crack an amazingly difficult scientific puzzle, maybe 10 years more