Tag: images

Universal Scaling

And this scrambling process happens very early indeed. In their papers this spring, Berges, Gasenzer and their collaborators independently described prescaling for the first time, a period before universal scaling that their papers predicted for nuclear collisions and ultracold atoms, respectively. Prescaling suggests that when a system first evolves from its initial, far-from-equilibrium condition, scaling exponents don’t yet perfectly describe it. The system retains some of its previous structure — remnants of its initial configuration. But as prescaling progresses, the system assumes a more universal form in space and time, essentially obscuring irrelevant information about its own past. If this idea is borne out by future experiments, prescaling may be the nocking of time’s arrow onto the bowstring.

Mars Geology

This week’s map is an artistic rendition of the geologic map of Mars designed by the USGS. I used the same geology data as the original map, but I added more topographic and label data, redesigned the visual style, and also edited the key for a more general audience. One of the most difficult parts of making this map was translating the key into plain English. The original USGS map was designed for geologists, so I had to look up almost all of the vocabulary. For example, my abbreviated definition for a caldera rim was “The rim of an empty magma chamber left behind after a volcanic eruption.” The original description was “Ovoid scarp, outlines single or multiple coalesced partial to fully enclosed depression(s); volcanic collapse, related to effusive and possibly explosive eruptions.”

Fake Politician

A well-respected local politician is elevated to one of the most powerful positions in France, but keeps his head down and gets on with the job instead of making an international media personality of himself. The perfect target for a most audacious identity theft.

“Everything about the story is exceptional. They dared to take on the identity of a serving French minister. Then they called up CEOs and heads of government round the world and asked for vast amounts of money. The nerve of it!”

Cell Compartmentalization

When compartmentalization was thought of as a singular feature of eukaryotes, experts were often forced to speculate about how it came about, what the biophysical constraints were, and what selective advantages it might have. “That’s where these prokaryotes become really interesting. If they show some features that are even mildly similar to what we see in eukaryotes, it allows us to broaden the question and attack from a different angle: Under what conditions might compartmentation provide some benefit? Or is it just the case that there’s no benefit whatsoever?” The bacterial cases “suggest that there are multiple ways to do this, and that there could be a strong evolutionary advantage to doing so.” That certainly seems to have been the case with energy production: The independent evolution of anammoxosomes in some kinds of bacteria and mitochondria in eukaryotes signify that “the compartmentalization of energy metabolism is beneficial to the cell. You see a trend in both prokaryotes and eukaryotes to compartmentalize certain traits or certain functions in order to better control them.”

2021-01-10: Biomolecular condensates are an emerging type of membrane-less organelle, and adding a lot to our understanding of cell compartmentalization.

Inside cells, droplets of biomolecules called condensates merge, divide and dissolve. Their dance may regulate vital processes. Biomolecular Condensates may explain the speed of many cellular processes. “The key thing about a condensate — it’s not like a factory; it’s more like a flash mob. You turn on the radio, and everyone comes together, and then you turn it off and everyone disappears”


2022-11-02: Condensates are getting more refined experiments to figure out what’s going on

After an initial rush to document the phenomenon in every nook and cranny of the cell, scientists are beginning to ask more detailed questions. They want to know what these globules are doing, how they form and, importantly, how to prove that these biomolecular condensates are really as widespread and essential to the cell as many reports have claimed. Researchers are also responding to critics who have questioned the accuracy of some descriptions of phase separation in cells, arguing that other forces besides phase separation could have created droplets.
Inside the condensates, enzymatic reactions were 36x faster. Condensates gave the process extra structure: they helped to organize the enzymes spatially, providing a molecular ‘scaffold’ so that they could more easily partner with their reactants. “You get this combined effect of increasing efficiency and increasing concentration”
Some in the community have sought to inject precision into the field and guide researchers in finding out whether a blob forms through phase separation or in some other way. Despite the debates in academia, drug hunters are embracing the concept. Most companies interested in phase separation are prioritizing drug development for cancer and neurological disorders, 2 disease classes frequently linked to condensates that have gone awry.

Solar System Orbit Map

This week’s map shows the orbits of 18k asteroids in the solar system. This includes everything we know of that’s over 10km in diameter – 10k asteroids – as well as 8k randomized objects of unknown size. This map shows each asteroid at its exact position on New Years’ Eve 1999. All of the data for this map is shared by NASA and open to the public. However, the data is stored in several different databases so I had to do a decent amount of data cleaning. I’ve explained all of the steps in detail in my open-source code and tutorial, so I’ll just include a sketch of the process here in this blog post.

APA Meeting Photo-Essay

You know how drug companies pay 6 or 7 figures for 30-second television ads just on the off chance that someone with the relevant condition might be watching? You know how they employ drug reps to flatter, cajole, and even seduce doctors who might prescribe their drug? Well, it turns out that having 15000 psychiatrists in 1 building sparks a drug company feeding frenzy that makes piranhas look sedate by comparison. Every flat surface is covered in drug advertisements. And after the flat surfaces are gone, the curved surfaces, and after the curved surfaces, giant rings hanging from the ceiling.