Biomechanical interactions, rather than neurons, control the movements of one of the simplest animals. The discovery offers a glimpse into how animal behavior worked before neurons evolved.
We show a minimal mechanism — trigger waves — by which these walking cells may work together to achieve organism-scale collaboration, such as coordination of hunting strikes across 100k cells without central control.
The behavior of Trichoplax can be described entirely in the language of physics and dynamical systems. Mechanical interactions that began at the level of a single cilium, and then multiplied over millions of cells and extended to higher levels of structure, fully explained the coordinated locomotion of the entire animal. The organism doesn’t “choose” what to do. Instead, the horde of individual cilia simply moves — and the animal as a whole performs as though it is being directed by a nervous system. The cilia’s dynamics exhibit properties that are commonly seen as distinctive hallmarks of neurons.

2022-03-30: Physical gradients
Much of the research to date on self-generated gradients has looked at chemical signals, but cells can create gradients in other physical attributes, too, including mechanical properties. The recent paper analyzing migrating neural crest cells revealed a self-generated gradient of stiffness.

2022-07-13: Embryogenesis involves the extracellular matrix contracting
Mechanical forces induce embryonic chicken skin to create follicles for growing feathers. Just as surface tension can pull water into spherical beads on a glass surface, so too can the physical tensions within an embryo set up patterns that guide growth and gene activity in developing tissues. As an organism grows and develops, the cells in its tissues pull and push on each other and on the supportive protein scaffolding (extracellular matrix) to which they are intricately linked. Some researchers have suspected that these forces, coupled with changes in the pressure and rigidity of the cells, might direct the formation of complicated patterns. Until now, however, no studies were able to tease apart the effect of these physical forces from the chemical stew in which they simmer.
