This places parents of young “foldit” enthusiasts in a quandary: should they tell their children to stop playing games and get on with their homework, or encourage them to continue playing and possibly share in a Nobel prize?
Tag: biotech
Gene Deextinction
Bringing Col2A1 back:
While other studies have examined extinct coding DNA function in vitro, this is the first example of the restoration of extinct non-coding DNA and examination of its function in vivo. Our method using transgenesis can be used to explore the function of regulatory and protein-coding sequences obtained from any extinct species in an in vivo model system, providing important insights into gene evolution and diversity.
Same deal for IRGM:
The exact reason that IRGM was reborn in species such as humans and apes, but not monkeys, is not yet completely understood. We do know, however, that the fact that most humans have a working copy of IRGM is quite fortuitous. As mentioned above, the IRG genes are essential to controlling bacteria, specifically by maintaining the delicate balance of bacterial growth and immune control in our intestines. Recent research has shown that those without a working copy of IRGM have a greater risk of developing Crohn’s Disease, in which an individual’s immune system begins attacking the friendly bacteria living in our guts.
Stupidity of Dignity
And what it reveals should alarm anyone concerned with American biomedicine and its promise to improve human welfare. For this government-sponsored bioethics does not want medical practice to maximize health and flourishing; it considers that quest to be a bad thing, not a good thing.
To understand the source of this topsy-turvy value system, one has to look more deeply at the currents that underlie the Council. Although the Dignity report presents itself as a scholarly deliberation of universal moral concerns, it springs from a movement to impose a radical political agenda, fed by fervent religious impulses, onto American biomedicine.
“dignity” in bioethics is thinly veiled religious nonsense.
In vitro meat
Many people have an initial reaction that invitro meat would be yucky and they do not want it. However, people already eat meat slurry in fairly large quantities.
Yuck – invitro meat. But deep fry it and call them improved McNuggets and they eat billions.
2012-02-15: Mark Post at Maastricht University
It looks more like squid than steak and because it lacks the fat and protein found in real cattle, does not taste like traditional beef. So why would anyone eat meat grown in a lab? In-vitro meat may still be years away from our supermarkets, but they will be able to grow a hamburger by the end of this year.
2015-01-01: Overblown title, but still interesting:
Why turn plant proteins into burgers? Why not just eat them as peas? Culture is a lump of flesh wrapped in dough. If you want to save the world, you’d better make it convenient. Sometime in the next 10 years, Beyond Meat or Impossible Foods or another rival will perfect vegetarian beef, chicken, and pork that is tastier, healthier, and cheaper than the fast-food versions of the real thing. Overnight, meat will become the coal of 2025—dirty, uncompetitive, outcast.
2016-03-23: Limit meat. Vindication!
The Netherlands Nutrition Center is recommending people eat just 2 servings of meat a week, setting an explicit limit on meat consumption for the first time. The recommendations come 5 years after a government panel weighed the ecological impact of the average Dutch person’s diet, concluding last year that eating less meat is better for human and environmental health.
2016-12-12: Beyond Meat
Most people have a vague feeling that factory farms aren’t quite ethical. But few people are willing to give up meat so such feelings are suppressed because acknowledging them would only make one feel guilty not just. Once the costs of giving up meat fall, however, vegetarianism will spread like a prairie wildfire changing eating habits, the use of farmland, and the science and economics of climate change.
as usual, don’t read the dumb comments.
2017-09-04: Memphis Meats
Memphis Meats is announcing their Series A syndicate today, and it is a fascinating group of people coming together to help the world modernize the manufacturing of meat by removing animals from the process. It is identical to the meat we eat, down to the cellular level; it’s just the manufacturing method that radically changes. For full disclosure, DFJ led the $17M Series A, and I’ll be joining the board. It has been hard to contain my excitement as I have been looking for a meat solution for 5 years now. Since signing the term sheet, I have been wearing their t-shirt for a month now, and it is quite an evangelical conversation starter, generating keen interest the likes of which I have rarely seen before (e.g., Bill Gates, Richard Branson and Kimbal Musk joined us). We also got leading research institutions and some of the largest meat industry corporations to join the syndicate.

2018-03-08: Wired piece on Memphis Meats
By January 2016 they had grown up enough for a taste test. At a cost of $1200, it was by far the most expensive meatball either man had ever eaten. The process is now orders of magnitudes more efficient. But there’s still more work to do. Clearing the cost hurdle will be key to cultured meat catching on. Consumers aren’t going to spring for a bioreactor burger if the farm-raised or grass-grazed version is 1000s of times less expensive. Valeti is feeling the pressure. “We need to get this expansion done in a timely fashion so it can actually make an impact while we still have a window. There’s definitely a race on.”
2018-04-06: Lobbyists are being hired
The beef industry has started to quiver, and rightfully so: Flush with untold capital, Impossible Foods has apparently decided to spend some of it on a Washington lobbyist. Back in 2016, people from Memphis Meats, Just (formerly Hampton Creek), and other “clean meat” start-ups banded together to form the Good Food Institute.
2019-04-02: Available in major chain restaurants
Burger King has announced that it is introducing a vegetarian Whopper on its menu. Burger King will test the new meatless option at 59 restaurants in the St. Louis area. If it proves popular, the “Impossible Whopper” will become available in all 7200 United States Burger King branches. Burger King is the latest fast food chain to add a vegetarian burger, following in the footsteps of Carl’s Jr. restaurants that added a vegetarian burger using Beyond Meat, in January and the “Impossible Slider” added by White Castle last year.
2019-06-27: Satanic Meatless burgers
Rick Wiles, host of TruNews, reveals that meatless burgers are “plant-based alternatives to meat and dairy products, is part of a satanic plot to alter human DNA so that people can no longer worship God.”
2019-09-30: Longer term, much more will be replaced:
Precision biology will displace, replace or transform agriculture by using designed microorganisms and adapting beer industry fermentation processes to produce food that is identical to milk and meat but without using animals. The first product we are seeing with mass impact is the Impossible Burger and Beyond Meat products that are impacting ground meat.

2019-12-11: Is Eating Meat A Net Harm?
Overall, the case for reduced meat consumption is strong. Vegetarianism is cheaper, better for your health (if you can afford a diverse diet and are not an infant), and is less impactful for the environment. It also has a significant moral cost in terms of animal suffering.
2020-01-07: Impossible Pork targeting the chinese market.
that tester agreed that the texture was off but the flavor was there. Lopatto tried a bánh mi sandwich, char siu buns, dan dan noodles, katsu, and sweet, sour, and numbing meatballs all made with Impossible Pork.
2020-03-13: Post-Zoonotic Food
There’s no time to waste in pushing forward solutions for what is likely the underlying cause of this pandemic, and what has been at the root of dozens of prior zoonotic events. We can’t afford not to have the same level of urgency in directing funding, effort, and talent into accelerating the development and deployment of safer, modern meat production methods. It is past time to move away from animal-derived meat altogether.
2020-08-07: CO2 and Methane impact
if every burger eaten in the USA were replaced with an Impossible burger, that would require 90% less land and water while reducing GHG emissions by 90%.
2021-05-14: Artificial Duck
My first taste of their cultivated meat, duck in this case. It was delicious and indistinguishable from duck, because it was duck. It just did not quack like a duck. Future generations will marvel that we thought we had to grow and slaughter a whole animal to get all the yummy meat that we might like to eat.
2021-07-15: Beyond Chicken
Some people do care about eating something that tastes exactly like chicken, so I took Beyond Chicken tenders to the toughest food critic I know: my 87-year-old grandmother. She’s been cooking incredible chicken dishes for decades, and I wanted to see if she’d sniff out the difference if I didn’t tell her that what she was being served was not real chicken. After taking a few bites, she said it tasted “very good.” Then I revealed to her that this was not real chicken; it was made from plants. She stared at me for 1 second. Then she said, “I don’t mind, as long as it tastes like chicken. And it does! It’s a bit heavier, but if you hadn’t said anything, I wouldn’t have noticed.”
But plant-based companies are not yet able to mimic chicken in all its forms. Making a breaded tender is one thing — the breading can act as camouflage. Creating a convincing chicken breast is a whole other dream, and Brown suggested we shouldn’t expect it to come true anytime soon.
2023-03-23: In vitro meat has tons of challenges, the plant alternatives are doing much better.
But while the industry releases increasingly optimistic projections, well-informed commentators remain skeptical. It’s still unclear if cultivated meat can be made affordable or at large-enough scale to compete with conventional animal products. As we approach the decade anniversary of Mark Post’s first burger, many are confused as to when, if ever, cultivated meat will be on their plates.
After spending a few years inside the industry, I’ve come to believe that the true prognosis for cultivated meat is somewhere in the middle, between that exuberant initial hopefulness and more recent cynicism. I agree with the pessimistic commentators that “The Dream” of cultivated meat — full bio-replicas, cost competitive, at scale — is not feasible in the short term. However, comparison to other technologies like solar energy suggests that cultivated meat may take decades and 100s of billions of dollars in investment — but is ultimately possible. If we accept longer time scales, many of the seemingly intractable problems become tractable. In the meantime, companies can justify large venture capital investments by pursuing cheaper products that combine cultivated and plant-based components.
Glycerol nucleic acid
“Making GNA is not tricky, it’s just 3 steps, and with 3 carbon atoms, only 1 stereo center. It allows us to make these right and left-handed biomolecules. People have actually made left-handed DNA, but it is a synthetic nightmare. To use it for DNA nanotechnology could never work. It’s too high of a cost to make, so one could never get enough material.” The ability to make mirror image structures opens up new possibilities for making nanostructures. The research team also found a number of physical and chemical properties that were unique to GNA, including having a higher tolerance to heat than DNA nanostructures.
interesting. GNA is simpler and more robust
Sequenomics
With detailed maps of the physiochemical properties spanning sequence space, and the practical tools to focus search in promising territories, Sequenomics transforms in vitro evolution from a shot in the dark to systematic search and recovery.
DARPA Hybrid Insect MEMS
The HI-MEMS program is aimed at developing tightly coupled machine-insect interfaces by placing micro-mechanical systems inside the insects during the early stages of metamorphosis. These early stages include the caterpillar and the pupae stages. Since a majority of the tissue development in insects occurs in the later stages of metamorphosis, the renewed tissue growth around the MEMS
Enzymes Built from Scratch
These proteins have no naturally occurring counterparts, and the reaction–which breaks down a man-made chemical–has no natural catalyst.
bakerlab++
Ice Man
Wim Hof should be dead for doing the following: running a half-marathon in the Arctic Circle in his bare feet, climbing the Everest in his shorts, and diving under the ice at the North Pole. Here’s a fascinating story about a 48-year-old Dutchman nicknamed “The Ice Man” for his uncanny ability of withstanding fatally freezing temperatures:
Normally, when a person is exposed to freezing temperatures for a prolonged period of time, the body goes into survival mode, as its liquids begin to freeze.
Frostbite sets in, and in order to save the major organs, the body sacrifices blood flow to the extremities, cutting circulation from the fingers, toes, ears and nose to keep the blood flowing to the organs necessary for survival.
If not treated immediately, the damage to these extremities is irreversible. The other danger is hypothermia, an abnormally low body temperature. At 0 celsius, body functions start shutting down, and once that starts, you could be dead within minutes.
But Hof stayed in his tomb of ice for 72 minutes. Then, the ice was poured out of the tank, and Hof emerged, his skin still pink.
“He’s not moving, he’s not generating heat, he’s not dressed for it, and he’s immersed in ice water. And water will transmit heat 30x faster than air. It literally sucks the life right out of you. And yet, despite all those negative factors, Wim Hof was very calm, very comfortable the entire time that he was immersed in that water
scan that guys dna already
IGEM
The iGEM Competition gives students the opportunity to push the boundaries of synthetic biology by tackling everyday issues facing the world. Made up of primarily university students, multidisciplinary teams work together to design, build, test, and measure a system of their own design using interchangeable biological parts and standard molecular biology techniques. Every year 6000 people dedicate their summer to iGEM and then come together in the fall to present their work and compete at the annual Jamboree.
looks like fun