Tag: ai

Batteries

This changes everything if it is not a mirage.

Stanford researchers have found a way to use silicon nanowires to reinvent the rechargeable lithium-ion batteries that power laptops, iPods, video cameras, cell phones, and countless other devices. The new technology produces 10x the amount of electricity of existing lithium-ion batteries. A laptop that now runs on battery for 2 hours could operate for 20 hours

2011-08-16: The progress in battery energy density has been very slow.

2019-04-25: 1000 Wh / kg? Though see their roadmap from a few years later that is more like 300 Wh / kg.

Innolith have the world’s first 1000 Wh/kg rechargeable battery. This would 3x the range of electric cars. The Innolith Energy Battery would radically reduce costs by not using exotic and expensive materials.


2020-10-14: AI battery research

In a paper published in Nature in February, Chueh and his colleagues described an experiment in which an AI was able to discover the optimal method for 10-minute fast-charging a lithium-ion battery. Finding optimal solutions in a huge search space is exactly the type of problem AI was built to solve. But until recently, battery-building AIs were hampered by a lack of data. “Historically, battery data has been very difficult to acquire because it’s not shared between researchers and companies”

2020-11-07: Structural batteries

While structural batteries for vehicles are highly rigid, the cell developed by Kotov’s team is meant to be pliable to cope with the movements of the robots. They’re also incredibly energy-dense. As Kotov and his team detailed in a paper published earlier this year, their structural batteries have 72 times the energy capacity of a conventional lithium-ion cell of the same volume. For now, their batteries are being used to power robotic toys and small drones as a proof of concept. He expects they’ll be used in midsize robots as well as larger hobby drones in the not-so-distant future. “Drones and medium-size robots need to have new solutions for energy storage. I can guarantee you that structural batteries will be a part of that.”

2022-04-15: Future battery technologies

On a longer time horizon, we consider Lithium-oxygen batteries an intriguing possibility. This class of battery derives energy by oxidizing pure lithium metal with a source of oxygen, traditionally in the form of ambient air. Reacting pure lithium with ambient oxygen can result in an electrochemical cell with the highest possible energy density of any metal, yielding theoretical capacities of 11k Wh/kg (not counting the weight of the reacted oxygen). This is noteworthy when Li-ion is today topping out at 250 Wh/kg, and Li-metal will theoretically top out around 3k Wh/kg. And especially interesting when you consider that liquid gasoline has a maximum energy density of 13k Wh/kg, with only 1.7k Wh/kg delivered to the wheels after losses. But a lithium-air battery in this basic configuration is not rechargeable. And significant technological challenges remain before any appreciable cycle-life is expected from batteries built with this technology. These lithium-air or lithium-oxygen batteries are at least 5–10 years away from commercialization, but could disrupt the market with a 10x step-change in energy density, rivaling liquid gasoline in terms of raw energy density.


2023-03-12: Li-S battery startup. Zeta’s cathode is based on a sulfurized carbon material that offers high stability and superior sulfur content, outperforming current metal-based cathode materials. Their sulfur-based cathodes are inherently inexpensive, have effective cost-per-energy use no cobalt and have 0 dependency on precious metal cost volatility or foreign nations.

Virtual AI Training

Virtual worlds also solved the problem of giving an AI a relatively unsophisticated environment in which it could live and learn. “I’m one of many AI theorists who believe that embodiment is important. Typing stuff back and forth does not give the AI much to go on in terms of understanding the world around it, or itself or its place in that world.”

ben goertzel’s pets come to second life

Sleep

the presence of jerks during rest in the gray whale, taken together with our previous data on 3 species of dolphins, allows us to suggest that short episodes of REM do exist in Cetaceans

2007-12-27: Orexin A Narcolepsy?

the absence of orexin A appears to cause narcolepsy. That finding pointed to a major role for the peptide’s absence in causing sleepiness. It stood to reason that if the deficit of orexin A makes people sleepy, adding it back into the brain would reduce the effects

2017-06-28: Whale sleep

Franco Banfi was following this pod of sperm whales when the giants suddenly seemed to fall into a vertical slumber. These massive marine mammals spend 7% of their time taking short (6- to 24-minute) rests in this shallow vertical position. Scientists think these brief naps may be the only time the whales sleep.

2017-10-31: Cocaine 2.0

Recent research has demonstrated the effectiveness of short light pulses to alter circadian phase during sleep in human subjects. 2-millisecond light flashes administered during sleep penetrate the eyelids and change circadian timing without interfering with sleep quality. Due to the properties of the retinal cells that transduce light information to the circadian system, these millisecond light flashes match or exceed the effectiveness of continuous bright light to shift circadian phase. More than 1.5 hours of phase shift can be generated with just over 1 total second of light exposure during 1 hour. LumosTech is developing a smart sleep mask that contains bright LEDs able to emit a range of millisecond light pulses at several frequencies. Light timing is controlled by a smartphone app that uses a proprietary algorithm to calculate the frequency and duration required for shifting circadian phase. The light stimulation is delivered during sleep in conjunction with a mathematical model of circadian phase to advance or delay sleep cycles. The mask contains additional LEDs that provide a red-wavelength dawn simulator to stimulate the release of cortisol; this promotes alertness and enhances mood immediately after wakeup.

2018-07-21: What we know about sleep

Our brain profoundly alters its behavior and purpose, dimming our consciousness. For a while, we become almost entirely paralyzed. We can’t even shiver. Our eyes, however, periodically dart about behind closed lids as if seeing, and the tiny muscles in our middle ear, even in silence, move as though hearing. We are sexually stimulated, men and women both, repeatedly. We sometimes believe we can fly. We approach the frontiers of death. We sleep. Around 2.35 ka BP, Aristotle wrote an essay, “On Sleep and Sleeplessness,” wondering just what we were doing and why. For the next 2300 years no one had a good answer. In 1924 German psychiatrist Hans Berger invented the electroencephalograph, which records electrical activity in the brain, and the study of sleep shifted from philosophy to science. It’s only in the past few decades, though, as imaging machines have allowed ever deeper glimpses of the brain’s inner workings, that we’ve approached a convincing answer to Aristotle.

2020-01-04: Sleep detox

An organized tide of brain waves, blood and spinal fluid pulsing through a sleeping brain may flush away neural toxins that cause Alzheimer’s and other diseases.

2020-11-10: Evening home lighting adversely impacts the circadian system and sleep

nearly 50% of homes had bright enough light to suppress melatonin by 50%, but with a wide range of individual responses (0–87% suppression for the average home). Greater evening light relative to an individual’s average was associated with increased wakefulness after bedtime. Homes with energy-efficient lights had 2x the melanopic illuminance of homes with incandescent lighting. Home lighting significantly affects sleep and the circadian system, but the impact of lighting for a specific individual in their home is highly unpredictable.

2021-05-18: Metabolic sleep

What, then, does sleep do in the absence of a brain? Raizen suspects that at least for some animals, sleep has a primarily metabolic function, allowing certain biochemical reactions to take place that can’t happen during waking hours. It may divert the energy that would be used by alertness and movement into other processes, ones that are too costly to take place while the animal is awake. For example, C. elegans seems to use sleep to enable the growth of its body and support the repair of its tissues. In sleep-deprived hydras, the cell divisions that are part of everyday life are paused. Something similar has been seen in the brains of sleep-deprived rats and in fruit flies. Managing the flow of energy may be a central role for sleep.

2021-11-16: Dreaming against overfitting

All of this begs the question of how the human brain deals with overfitting. Our day-to-day experience can be hugely repetitive, so how does the brain generalize from these singular experiences to other situations?

The human brain prevents overfitting by dreaming. Dreaming evolved specifically to deal with this problem, which is common to all neural networks. If this theory is correct, it answers one of the great unsolved problems in neuroscience: why we dream at all.

2022-08-07: Spider REM Sleep?

When Rößler recorded 34 sleeping spiderlings, she found that their twitches were accompanied by unmistakable eye-tube movements that did not happen during other phases of sleep. “It’s beautiful. I mean, it’s crazy. It immediately makes a sleep researcher think about rapid eye movement sleep”. Dreaming offers an entry point into questions of awareness in other animals: it is difficult to imagine that even a simple dream is possible without something like an ego or an “I” experiencing it, he adds. So if spiders dream, it might mean that we start talking about spiders having something like a minimal self.

2023-09-10: REM sleep is body-mapping

The brain uses REM sleep to “learn” the body. You wouldn’t think that the body is something a brain needs to learn, but we aren’t born with maps of our bodies; we can’t be, because our bodies change by the day, and because the body a fetus ends up becoming might differ from the one encoded in its genome. “Infants must learn about the body they have. Not the body they were supposed to have.”

As a human fetus, you have 9 months in a dark womb to figure out your body. If you can identify which motor neurons control which muscles, which body parts connect, and what it feels like to move them in different combinations, you’ll later be able to use your body as a yardstick against which to measure the sensations you encounter outside. It’s easier to sense food in your mouth if you know the feeling of a freely moving tongue; it’s easier to detect a wall in front of you if you know what your extended arm feels like unimpeded. In waking life, we don’t tend to move only a single muscle; even the simple act of swallowing employs some thirty pairs of nerves and muscles working together. Our sleep twitches, by contrast, are exacting and precise; they engage muscles one at a time. Twitches “don’t look anything like waking movements. They allow you to form discrete connections that otherwise would be impossible.”

The theory turned the rationale for REM paralysis on its head: the paralysis isn’t there to stop the twitches but to highlight them. It’s a process that’s most important in infancy, but this might continue throughout our lives, as we grow and shrink, suffer injuries and strokes, make new motor memories and learn new skills. Blumberg plays the drums, and, when he learns a new rhythm, he wonders whether sleep is involved. “You struggle and struggle for several days, then one day you wake up and start playing and boom—it’s automatic. Did sleep play a role in that? If I had been recording my limb movements, would I have seen something interesting? That keeps me up at night.”

2023-10-22: Dream communication

While they were sleeping, participants were repeatedly asked to frown or smile. All of them responded accurately to at least 70% of these prompts.

Overall response rates were higher for all participants during REM (rapid eye movement) sleep, when the deepest sleep occurs but the brain remains quite active, than during other sleep stages.

Robot Audition

The audition system of the highly intelligent humanoid requires localization of sound sources and identification of meanings of the sound in the auditory scene. The active audition focuses on improved sound source tracking by integrating audition, vision, and motor movements. Given the multiple sound sources in the auditory scene, “SIG the humanoid” actively moves its head to improve localization by aligning microphones orthogonal to the sound source and by capturing the possible sound sources by vision. However, such an active head movement inevitably creates motor noise. The system must adaptively cancel motor noise using motor control signals. The experimental result demonstrates that the active audition by integration of audition, vision, and motor control enables sound source tracking in variety of conditions.

can handle 3 simultaneous spoken orders at 70% comprehension with no training. with demo videos.

Antibiotics

For all you antibacterial soap-using dummies.

Unlike (soap and other) traditional cleaners, antibacterial products leave surface residues, creating conditions that may foster the development of resistant bacteria. Alcohol-based hand sanitizers are just about as effective against germs as soap and water. They’re also easier on your skin than hand-washing, and unlike antibacterial soaps, they don’t breed antibiotic-resistant superbacteria.

The bottom line is that you shouldn’t live in fear of high-traffic surfaces. This type of contact simply isn’t the way people get sick.

2010-11-08: We are essentially back to an era with no antibiotics

This new resistance pattern has been reported in many different types of bacteria compared to previously and 10% of these NDM1-containing strains appears to be pan-resistant, which means that there is no known antibiotic that can treat it. A second concern is that there is no significant new drug development for antimicrobials.

2015-01-08: New Antibiotics Platform?

A lot of people have had similar ideas to this one, based on the fact that the overwhelming majority of bacteria in any given environmental sample can’t be readily cultured. These organisms may well be able to produce useful antibiotics and other natural products, but how will you ever be able to tell if you can’t fish any of them out? Using this on a soil sample from Maine and leaving the chip in situ for a month, a number of colonies formed. These were tested for their ability to grow outside the device in fermentation broth, and extracts of these were tested against pre-grown lawns of an S. aureus strain to look for useful antibiotic activity. Lo and behold, one extract cleared out a large spot – it turned out to come from a newly described bacterium (Eleftheria terrae, provisionally). The compound present has been named teixobactin, and here it is. So how useful is the compound? It’s active only against gram-positive organisms, which is too bad, because we could really use some new gram-negative killers (their cell membranes make them a tougher breed). But the mechanism of action turns out to be interesting: studies of S. aureus with labeled precursors showed that teixobactin is a peptidoglycan synthesis inhibitor, but extended exposure and passaging did not yield any resistant strains. That’s close to impossible if an antibiotic is binding a particular protein target – stepping on the selection pressure will usually turn up something that evades the drug. When you don’t see that, it’s often because there’s some nonspecific non-protein-targeted mechanism, which can be problematic, but teixobactin isn’t toxic to eukaryotic cells in culture (and has a favorable tox profile in mice as well). It turns out that it binds to some of the peptidoglycan precursors, lipid II and lipid III. Vancomycin has a similar mechanism (binding to lipid II), but teixobactin has a wider spectrum of activity against lipid II variants (and lipid III as well). This mechanism makes developing resistance not so straightforward – the selection pressure is more of a bounce shot than a direct hit.

2015-02-24: Antibiotics market failure

we seem willing to pay $100K or more for cancer drugs that cure no one and at best add weeks or a few months to life. We are willing to pay 1$0Ks for knee surgery that, at best, improves function but is not lifesaving. So why won’t we pay $10K for a lifesaving antibiotic?

2015-03-31: Medieval salve kills MRSA. Impressive! Not all ancient medical knowledge is homeopathic nonsense.

Take cropleek and garlic, of both equal quantities, pound them well together… take wine and bullocks gall, mix with the leek… let it stand 9 days in the brass vessel

So goes a 1000-year-old Anglo Saxon recipe to vanquish a stye, an infected eyelash follicle. If the 9th Century recipe does lead to new drugs, they might be useful against MRSA skin infections such as those that cause foot ulcers in people with diabetes. These are usually antibiotic-resistant

2016-01-23: Antibiotics synthesis

Antibiotics are generally synthesized in nature by bacteria (or other microbes) as defenses against each other. We have identified antibiotics in the lab, and thus necessarily only those made by bacterial species that we can grow in the lab. Almost all bacterial species cannot be grown in the lab using practical methods. That hasn’t changed for decades. But those bacteria grow fine in the environment, typically the soil. So… can we isolate antibiotics from the soil?

2018-05-21: Phage Therapy

3 months earlier, Patterson had suddenly fallen ill, so severely that he had to be medevaced to Germany and then to UCSD. There were several things wrong—a gallstone, an abscess in his pancreas—but the core of the problem was an infection with a superbug, a bacterium named Acinetobacter baumannii that was resistant to every antibiotic his medical team tried to treat it with. Patterson was wasted, his cheekbones jutting through his skin. Intravenous lines snaked into his arms and neck, and tubes to carry away seepage pierced his abdomen. He was delirious and his blood pressure was falling, and the medical staff had sedated him and intubated him to make sure he got the oxygen he needed. He was dying. … “We are running out of options to save Tom. What do you think about phage therapy?”

2019-11-04: CRISPR Antibiotics

An alarming number of bacteria are now resistant to one or more antibiotics, so this new line of inquiry would certainly be welcomed if it proves effective.

In their recent study, Dr. Edgell and his colleagues successfully used a Crispr-associated enzyme called Cas9 to eliminate a species of Salmonella. By programming the Cas9 to view the bacterium itself as the enemy, Dr. Edgell and his colleagues were able to force Salmonella to make lethal cuts to its own genome.

As we discover more of the benefits of our microbiota, it would also be interesting to have a solution to bacterial infections which doesn’t create problems for our “good bacteria.

2020-02-22: Antibiotics ML

So overall, this is an impressive paper. The combination of what appears to be pretty rigorous ML work with actual assay data generated just for this project seems to have worked out well, and represents, I would say, the current state of the art. It is not the “Here’s your drug!” virtual screening of fond hopes and press releases, but it’s a real improvement on what’s come before and seems to have generated things that are well worth following up on. I would be very interested indeed in seeing such technology applied to other drug targets and other data sets – but then, that’s what people all around academia and industry are trying to do right now. Let’s hope that they’re doing it with the scope and the attention to detail presented in this work.

2020-07-24: SCH-79797

Researchers have found a compound, SCH-79797, that can simultaneously puncture bacterial walls and destroy folate within their cells — while being immune to antibiotic resistance. This is the first antibiotic that can target Gram-positives and Gram-negatives without resistance

2020-08-07: Maybe the non-profit route will work

If something isn’t done now, antibiotic-resistant bacteria could kill as many as 10M people a year by 2050. A little-known Boston nonprofit could be our best hope.

2021-07-28: Biofilms are nasty

This discovery underscores how important it is to include biofilms in any studies of antibacterial compounds because being able to kill planktonic cultures bears no relation to being able to break down biofilm.

2021-10-14: Another approach is to modify bacteria to destroy the MSRA biofilms

Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated bacterial infections. This strain has a unique genetic code, which hinders gene transfer to most other bacterial genera, and it lacks a cell wall, which allows it to express proteins that target peptidoglycans of pathogenic bacteria. We first determined that removal of the pathogenic factors fully attenuated the chassis strain in vivo. We then designed synthetic promoters and identified an endogenous peptide signal sequence that, when fused to heterologous proteins, promotes efficient secretion. Based on this, we equipped the chassis strain with a genetic platform designed to secrete antibiofilm and bactericidal enzymes, resulting in a strain capable of dissolving Staphylococcus aureus biofilms preformed on catheters in vitro, ex vivo, and in vivo. To our knowledge, this is the first engineered genome-reduced bacterium that can fight against clinically relevant biofilm-associated bacterial infections.

2023-05-23: Odd that phage therapy only made progress in former soviet republics

“Phages” are little known outside the former countries of the Soviet Union, which did the most to develop the idea. In Georgia they have been part of the local pharmacopoeia for decades. (Indeed, 2023 marks the Eliava’s centenary.) Little vials containing stale-tasting liquid full of anti-bacterial viruses can be bought at pharmacies across Tbilisi. Now, as worries about antibiotic resistance build, Western firms are taking a second look.