<?xml version="1.0" encoding="utf-8"?>
<feed xmlns="http://www.w3.org/2005/Atom" xmlns:thr="http://purl.org/syndication/thread/1.0">
  <title>Gregor J. Rothfuss</title>
  <subtitle>Thoughts, notes, and curated knowledge across 27 years.</subtitle>
  <link rel="hub" href="https://pubsubhubbub.appspot.com/"/>
  <link rel="hub" href="https://websub.feedly.com/"/>
  <link href="https://gregor.fyi/atom.xml" rel="self" type="application/atom+xml"/>
  <link href="https://gregor.fyi/" rel="alternate" type="text/html"/>
  <id>https://gregor.fyi/</id>
  <updated>2026-10-06T16:37:50Z</updated>
  <author><name>Gregor J. Rothfuss</name></author>
  <entry>
    <title>Divergent AI Strategies</title>
    <link href="https://gregor.fyi/2026/10/06/divergent-ai-strategies/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/10/06/divergent-ai-strategies/</id>
    <published>2026-10-06T12:35:00Z</published>
    <updated>2026-10-06T12:35:00Z</updated>
    <content type="html"><![CDATA[<blockquote>While the American AI strategy models development as a winner-take-all race toward artificial general intelligence through LLM scaling, Chinese policy explicitly rejects this framing. China’s AI+ Plan does not mention America or race dynamics; instead, it subsidizes open-weight foundation models via local compute vouchers to drive broad industrial diffusion into manufacturing and domestic supply chains. The divergence is between a centralized moonshot for frontier superintelligence and decentralized technological integration into physical industry. <a href="https://www.palladiummag.com/2026/10/06/rationalism-and-divergent-sinomodernity/">palladiummag.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>NTP reimplementation: Stateless Network Time Security</title>
    <link href="https://gregor.fyi/2015/03/28/ntp-reimplementation/#2026-10-06" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2015/03/28/ntp-reimplementation/#2026-10-06</id>
    <published>2026-10-06T12:00:00Z</published>
    <updated>2026-10-06T12:00:00Z</updated>
    <thr:in-reply-to ref="https://gregor.fyi/2015/03/28/ntp-reimplementation/" href="https://gregor.fyi/2015/03/28/ntp-reimplementation/" type="text/html"/>
    <content type="html"><![CDATA[<p class="update-context"><em>Update to <a href="https://gregor.fyi/2015/03/28/ntp-reimplementation/">NTP reimplementation</a>:</em></p>
<blockquote>Meta deployed Network Time Security (RFC 8915) across its public infrastructure at nts.meta.com and open-sourced the full protocol, server, and client implementation in their Time library. To handle Meta-scale traffic without memory bloat, their NTS servers maintain 0 per-client state: cookie keys are derived ephemerally via symmetric cryptography rather than stored or replicated. Having previously pushed internal precision from 10 milliseconds down to 100 microseconds, this transition shifts focus from sub-millisecond clock drift to cryptographic authenticity, eliminating on-path packet spoofing against TLS certificate validation and token expirations. <a href="https://engineering.fb.com/2026/10/06/production-engineering/nts-authenticated-time-at-meta/">engineering.fb.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Iron and Bronze Collapse</title>
    <link href="https://gregor.fyi/2026/10/02/iron-and-bronze-collapse/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/10/02/iron-and-bronze-collapse/</id>
    <published>2026-10-02T12:08:11Z</published>
    <updated>2026-10-02T12:08:11Z</updated>
    <content type="html"><![CDATA[<blockquote>The question is not why Bronze Age empires fell, but why nothing like them returned for centuries. The causes of the Bronze Age collapse are debated — droughts, the Sea Peoples, internal revolts. But a decisive factor was iron. While the tin required for bronze was concentrated in rare deposits and easily monopolized by imperial courts, iron is the 4th most abundant element in Earth’s crust. In contrast to bronze, iron democratized violence. Because iron could be produced locally, imperial centers permanently lost their monopoly on the tools of war, ending the centralized equilibrium that had sustained Bronze Age states for 1,000 years. <a href="https://www.worksinprogress.news/p/why-really-caused-the-bronze-age">worksinprogress.news</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Agentic Verification</title>
    <link href="https://gregor.fyi/2026/09/30/agentic-verification/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/30/agentic-verification/</id>
    <published>2026-09-30T20:09:42Z</published>
    <updated>2026-09-30T20:09:42Z</updated>
    <content type="html"><![CDATA[<blockquote>Across 26 prompt conditions tested on Rust implementations (TLA+, Alloy, Verus, Kani, fuzzing), default unprompted coding outperformed most specialized verification prompts. Agents overwhelmingly wrote code first rather than modeling upfront: 75 out of 80 agents told to use TLA+ implemented in Rust first, then used TLA+ post-hoc on trivial functions where pass rates were already 99.6%, while completely failing to model concurrency, event queues, and state machines where the actual failures occurred. <a href="https://danluu.com/agentic-testing">danluu.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Post-Proof Mathematics</title>
    <link href="https://gregor.fyi/2026/09/30/post-proof-mathematics/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/30/post-proof-mathematics/</id>
    <published>2026-09-30T17:15:00Z</published>
    <updated>2026-09-30T17:15:00Z</updated>
    <content type="html"><![CDATA[<blockquote>We cannot suddenly move the goalposts and pretend that proving theorems was never the point, or that open problems were merely proxies for mathematical understanding. For quite some time, the implicit social contract has been that society pays us to exercise our intellectual curiosity and we, in return, provide skills and practical knowledge. In a world where models match or exceed humans at proving theorems, that social contract needs to be renegotiated with humility rather than entitlement. Even if this future supports fewer professional mathematicians, it could nevertheless support a much richer mathematical life. <a href="https://theorydish.blog/2026/09/29/speeding-up-the-process-of-mourning/">theorydish.blog</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Commerce vs Extraction in City Formation</title>
    <link href="https://gregor.fyi/2026/09/28/commerce-vs-extraction-in-city-formation/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/28/commerce-vs-extraction-in-city-formation/</id>
    <published>2026-09-28T08:40:00Z</published>
    <updated>2026-09-28T08:40:00Z</updated>
    <content type="html"><![CDATA[<blockquote>In economic history, DeLong and Shleifer show that in second-millennium Europe, city growth correlated with non-absolutist government. Unlike the urban elites of antiquity, medieval elites were rural, making urban population a proxy for commerce rather than imperial extraction. London grew as a river crossing and commercial center before Norman royal institutions centralized around Westminster, while Hanseatic cities formed entirely along maritime trade networks, obtaining imperial immediacy as functional city-states dependent on imported grain from lands they did not rule. <a href="https://pedestrianobservations.com/2026/09/27/the-origin-of-premodern-western-cities/">pedestrianobservations.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Agents, Computers, and Volition</title>
    <link href="https://gregor.fyi/2026/09/28/agents-computers-and-volition/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/28/agents-computers-and-volition/</id>
    <published>2026-09-28T08:35:00Z</published>
    <updated>2026-09-28T08:35:00Z</updated>
    <content type="html"><![CDATA[<blockquote>The key thing to understand about agents is that they are an AI with access to a computer: probabilistic LLMs leveraging deterministic computers to do computer things. When distribution became free, publishing became abundant and curation was scarce. With agents, the raw capability to execute tasks is becoming abundant; what remains scarce is human volition. While base models are substitutable commodities, agents improve with accumulated user context, and that persistent context becomes the dominant switching cost. <a href="https://stratechery.com/2026/apps-agents-and-aggregation/">stratechery.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Regulatory Freezing of Engineered Microbes</title>
    <link href="https://gregor.fyi/2026/09/28/regulatory-freezing-of-engineered-microbes/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/28/regulatory-freezing-of-engineered-microbes/</id>
    <published>2026-09-28T08:30:00Z</published>
    <updated>2026-09-28T08:30:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Engineers at UT Austin modified wild PET-eating bacterial enzymes to create FAST-PETase, which breaks down polyethylene terephthalate in under 24 hours instead of six weeks. Similar bioleaching strains extract rare earth metals 73 percent faster than natural microbes. Yet environmental deployment remains frozen under the 1986 Toxic Substances Control Act (TSCA): of more than 240 applications filed between 1987 and 2018, almost none were approved, because any intergeneric marker gene classifies the living organism as a synthetic chemical. <a href="https://www.worksinprogress.news/p/all-the-microbes-you-cant-have">worksinprogress.news</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Where’s the “intelligence explosion”?</title>
    <link href="https://gregor.fyi/2026/09/27/wheres-the-intelligence-explosion/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/27/wheres-the-intelligence-explosion/</id>
    <published>2026-09-27T11:00:05Z</published>
    <updated>2026-09-27T11:00:05Z</updated>
    <content type="html"><![CDATA[<blockquote>Given our best current data, the AI self-improvement loop would need to be roughly 5–10× stronger to sustain itself, let alone run away. I expect incredibly rapid AI progress by the standards of nearly any other technology. But the evidence we have doesn’t suggest a sudden explosion to incomprehensible superintelligence anytime soon. <a href="https://www.noahpinion.blog/p/wheres-the-intelligence-explosion">noahpinion.blog</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Global Fossil Emissions Drop</title>
    <link href="https://gregor.fyi/2026/09/27/global-fossil-emissions-drop/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/27/global-fossil-emissions-drop/</id>
    <published>2026-09-27T11:00:05Z</published>
    <updated>2026-09-27T11:00:05Z</updated>
    <content type="html"><![CDATA[<blockquote>Global carbon emissions and fossil fuel consumption are dropping in their first annual decline since the peak of the 2020 coronavirus lockdowns. Persistent supply shortages and high energy prices are suppressing oil and gas usage worldwide, with crude demand averaging 102 million barrels per day compared to 91 million in 2020. <a href="https://marginalrevolution.com/marginalrevolution/2026/09/earth-fact-of-the-day-2-2.html">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Should you text more?</title>
    <link href="https://gregor.fyi/2026/09/26/should-you-text-more/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/26/should-you-text-more/</id>
    <published>2026-09-26T11:00:05Z</published>
    <updated>2026-09-26T11:00:05Z</updated>
    <content type="html"><![CDATA[<blockquote>Here, in five waves of panel data ( N = 1,966 US adults), we examined associations between life satisfaction and self-reported use of ten common social technologies measured every 3 months on a six-point frequency scale from ‘I did not use’ to ‘multiple times daily’. At this measurement level and timescale, Bayesian and frequentist random-intercept cross-lagged panel models showed little credible evidence that any social technology use predicts subsequent life satisfaction. In the reverse direction, increases in life satisfaction predicted only modest increases in (video) calling in select demographic groups. In analyses comparing different people, frequency of texting was associated with higher life satisfaction, whereas frequency of YouTube and TikTok use was associated with lower life satisfaction. Despite limited ability to detect within-person change due to temporal stability in responses, the absence of cross-lagged effects is informative: there is scant evidence of a meaningful relationship between social technology use and subsequent life satisfaction. <a href="https://marginalrevolution.com/marginalrevolution/2026/09/should-you-text-more.html">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>The Specter of Neuralese</title>
    <link href="https://gregor.fyi/2026/09/25/the-specter-of-neuralese/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/25/the-specter-of-neuralese/</id>
    <published>2026-09-25T09:00:00Z</published>
    <updated>2026-09-25T09:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Inside a transformer, computation happens as geometric transformations across a high-dimensional continuous latent space. But under standard chain-of-thought, the model is forced at each cycle to collapse that rich latent state through a bottleneck: projecting it into discrete tokens—twenty-six glyphs invented by Phoenician turquoise miners in 1800 BC—written onto an English scratchpad, which must then be re-embedded back into latent space before the next layer can touch it.

This bottleneck is a severe capability tax, but an accidental alignment godsend: humans can monitor intermediate thinking in plain English. The specter of 'neuralese recurrence' is what happens when you cut out the middleman and loop the computation directly within latent space—letting the model circulate raw activation vectors indefinitely without ever translating into human glyphs. It unbottlenecks thought, but leaves us completely blind, because interpretability has no dictionary for arbitrary thousand-dimensional latent trajectories. <a href="https://www.astralcodexten.com/p/the-specter-of-neuralese">astralcodexten.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>LLM Watermarking at Scale</title>
    <link href="https://gregor.fyi/2026/09/24/llm-watermarking-at-scale/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/24/llm-watermarking-at-scale/</id>
    <published>2026-09-24T18:00:00Z</published>
    <updated>2026-09-24T18:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Anthropic has announced that it’s now watermarking the outputs of Claude, using a scheme based on Google’s SynthID, which is in turn based on the Gumbel Softmax scheme that I proposed at OpenAI back in 2022—as far as I know, the first LLM watermarking proposal, though far from the last one. <a href="https://scottaaronson.blog/?p=10032">scottaaronson.blog</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>The Bathymetry of Tulainyo Lake</title>
    <link href="https://gregor.fyi/2026/09/24/depth-of-tulainyo-lake/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/24/depth-of-tulainyo-lake/</id>
    <published>2026-09-24T14:00:00Z</published>
    <updated>2026-09-24T14:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>No-one knew how deep the highest large lake in the Sierra was, so we carried a packraft over Shepherd Pass and found out: 117 m. 93 km walked, 6 days, and 4.7 km paddled at 12,900 ft.

Wikipedia claimed not to know. We commissioned satellite imagery to confirm it was ice-free, hauled an ultralight packraft and sonar sounder up the brutal Shepherd Pass trail, and sounded the basin. USGS topography predicted 25–40 meters. The actual sounding: 117 meters (384 feet), making it the 25th deepest natural lake in North America, and by far the deepest lake on Earth for its surface area. <a href="https://adventures.caseyhandmer.com/tulainyo.html">caseyhandmer.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Celtic Sword Metallurgy</title>
    <link href="https://gregor.fyi/2026/09/23/celtic-sword-metallurgy/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/23/celtic-sword-metallurgy/</id>
    <published>2026-09-23T21:00:00Z</published>
    <updated>2026-09-23T21:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Polybius famously claimed that Gaulish Celtic warriors were crippled in battle because their longswords bent upon impact and had to be straightened with the foot. Metallurgical spectroscopy of excavated La Tène Iron Age blades refutes the Roman account as wartime propaganda: Celtic smiths had mastered pattern welding, carburized high-carbon cutting edges, and quench hardening, producing weapons so mechanically superior that the Roman army discarded their native blades to adopt the Celtic design as the <i>gladius Hispaniensis</i>. <a href="https://en.wikipedia.org/wiki/Iron_Age_sword">wikipedia.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>OKLCH and Perceptual Uniformity</title>
    <link href="https://gregor.fyi/2026/09/23/oklch-color-space/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/23/oklch-color-space/</id>
    <published>2026-09-23T20:00:00Z</published>
    <updated>2026-09-23T20:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Traditional RGB and HSL color models suffer from severe perceptual non-uniformity: yellow and blue share identical nominal lightness values in HSL despite human photoreceptors perceiving yellow as dramatically brighter. In Björn Ottosson's OKLCH color space, perceived lightness and chroma are mathematically decoupled from polar hue angle, enabling programmatic palette shifts and algorithmic contrast ratios that stay aesthetically invariant and WCAG-compliant without manual eye-tuning. <a href="https://bottosson.github.io/posts/oklab/">bottosson.github.io</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Active Noise Cancellation Latency Budget</title>
    <link href="https://gregor.fyi/2026/09/23/anc-latency-physics/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/23/anc-latency-physics/</id>
    <published>2026-09-23T17:00:00Z</published>
    <updated>2026-09-23T17:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Feedforward active noise cancellation in headphones operates against one of the tightest physical latency ceilings in commercial computing: with sound traveling through air at 343 m/s, an acoustic disturbance takes approximately 44 microseconds to physically traverse the 15 mm gap between an exterior microphone and the ear canal. Sampling, ADC conversion, DSP phase inversion, and speaker diaphragm actuation must complete entirely within that 40-microsecond window before the pressure wavefront passes the eardrum. <a href="https://en.wikipedia.org/wiki/Active_noise_control">wikipedia.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>The History of Fishes</title>
    <link href="https://gregor.fyi/2026/09/23/history-of-fishes/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/23/history-of-fishes/</id>
    <published>2026-09-23T13:00:00Z</published>
    <updated>2026-09-23T13:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>In 1686, the Royal Society drained its entire treasury underwriting Francis Willughby's lavishly engraved <i>De Historia Piscium</i> (The History of Fishes). The volume flopped catastrophically, leaving the Society completely broke and unable to finance Isaac Newton's <i>Principia Mathematica</i>; Edmond Halley had to step in and fund the publication of Newton's masterwork out of his own pocket, while being partially compensated by the Society in unsold copies of fish books. <a href="https://en.wikipedia.org/wiki/De_Historia_Piscium">wikipedia.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Earth-Moon Cyclers</title>
    <link href="https://gregor.fyi/2026/09/23/earth-moon-cyclers/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/23/earth-moon-cyclers/</id>
    <published>2026-09-23T09:00:00Z</published>
    <updated>2026-09-23T09:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Families of stable, prograde, low-energy Earth-Moon cycler orbits loop between geocentric and selenocentric trajectories indefinitely without propulsion or station-keeping propellant: resonant gravity assists from both bodies naturally maintain the repeating shuttle corridor, eliminating the heavy fuel overhead required to accelerate and decelerate large habitat shielding on cis-lunar transit runs. <a href="https://en.wikipedia.org/wiki/Lunar_cycler">wikipedia.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Bologna Porticoes and Air Rights</title>
    <link href="https://gregor.fyi/2026/09/22/bologna-porticoes/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/22/bologna-porticoes/</id>
    <published>2026-09-22T18:00:00Z</published>
    <updated>2026-09-22T18:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Bologna's 62 km network of covered pedestrian porticoes emerged from an 11th-century property rights covenant: the municipality granted private owners the air rights to expand second-floor living quarters over the public street on the strict condition that the ground floor remained an unobstructed, covered public arcade. Aligned incentives built the world's longest sheltered urban pedestrian network without public expenditure. <a href="https://en.wikipedia.org/wiki/Porticoes_of_Bologna">wikipedia.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Synthetic Methanol at Scale</title>
    <link href="https://gregor.fyi/2026/09/22/terraform-methanol/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/22/terraform-methanol/</id>
    <published>2026-09-22T14:00:00Z</published>
    <updated>2026-09-22T14:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Terraform Industries demonstrated megawatt-scale high-purity methanol synthesis at their Muroc desert test site: gas fermentation and catalytic methanation convert atmospheric CO2 and electrolytic green hydrogen into dense liquid hydrocarbon feedstocks, decoupling global chemical production and maritime transport fuels from fossil oil wells. <a href="https://terraformindustries.com/">terraformindustries.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Phytomining</title>
    <link href="https://gregor.fyi/2026/09/22/phytomining/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/22/phytomining/</id>
    <published>2026-09-22T10:00:00Z</published>
    <updated>2026-09-22T10:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Hyperaccumulator plants concentrate elements from soil into dry biomass at extraordinary ratios: species like <i>Astragalus bisulcatus</i> and <i>Phyllanthus balgooyi</i> accumulate up to 13.6 g/kg of selenium or 25% nickel in sap, turning biological cultivation, harvesting, and ash purification into commercial metal extraction without open-pit excavation or chemical tailing ponds. <a href="https://en.wikipedia.org/wiki/Phytomining">wikipedia.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Cosmic Hunt</title>
    <link href="https://gregor.fyi/2026/09/21/cosmic-hunt/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/21/cosmic-hunt/</id>
    <published>2026-09-21T12:00:00Z</published>
    <updated>2026-09-21T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Phylogenetic analysis of oral traditions traces the Cosmic Hunt—a celestial cervid or bear pursued into the sky by hunters whose arrows pin it to the heavens—across Eurasia and North America, dating the core circumpolar asterism of Ursa Major to the Upper Paleolithic Beringian migration over 15,000 years ago. <a href="https://hal.science/halshs-00806454">hal.science</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Cavity Magnetron</title>
    <link href="https://gregor.fyi/2026/09/18/cavity-magnetron/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/18/cavity-magnetron/</id>
    <published>2026-09-18T12:00:00Z</published>
    <updated>2026-09-18T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>The cavity magnetron invented by Randall and Boot unlocked high-power 10 cm centimetric radar compact enough to mount inside aircraft radomes. Hand-carried to the US in the 1940 Tizard Mission, it decisively shifted maritime patrol interception against surfaced U-boats before Percy Spencer repurposed its stray microwave radiation for domestic cooking. <a href="https://en.wikipedia.org/wiki/Cavity_magnetron">wikipedia.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Solein</title>
    <link href="https://gregor.fyi/2026/09/15/solein/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/15/solein/</id>
    <published>2026-09-15T12:00:00Z</published>
    <updated>2026-09-15T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Solein decouples complete protein synthesis from arable land, irrigation, and nitrogen runoff: gas-fermenting hydrogen-oxidizing bacteria (<i>Cupriavidus necator</i>) convert green electrolytic hydrogen, carbon dioxide, and ammonia into an edible single-cell biomass yielding 70% protein with all essential amino acids. <a href="https://solarfoods.com/solein/">solarfoods.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Liechtenstein Monarchy</title>
    <link href="https://gregor.fyi/2026/09/12/liechtenstein-monarchy/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/12/liechtenstein-monarchy/</id>
    <published>2026-09-12T12:00:00Z</published>
    <updated>2026-09-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Liechtenstein's constitutional monarchy pairs genuine princely executive veto power with unilateral municipal secession rights: the credible threat of local secession disciplines monarchical governance without requiring parliamentary gridlock. <a href="https://marginalrevolution.com/marginalrevolution/2026/09/is-lichtenstein-an-actual-monarchy.html">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Surgical Amygdalectomy Limits</title>
    <link href="https://gregor.fyi/2026/09/08/surgical-amygdalectomy-limits/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/08/surgical-amygdalectomy-limits/</id>
    <published>2026-09-08T12:00:00Z</published>
    <updated>2026-09-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Complete bilateral surgical ablation of the amygdala abolishes pathological fear conditioning and severe aggression but impairs social risk evaluation and ambient threat perception, illustrating the acute trade-offs inherent in modular neuroanatomy. <a href="https://www.astralcodexten.com/p/absurd-adventure-and-amygdalectomy">astralcodexten.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>GLP-1 in Aging</title>
    <link href="https://gregor.fyi/2026/09/04/glp-1-in-aging/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/09/04/glp-1-in-aging/</id>
    <published>2026-09-04T12:00:00Z</published>
    <updated>2026-09-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>GLP-1 receptor agonists function as systemic geroprotectors by suppressing chronic vascular inflammation, improving endothelial hemodynamics, and downregulating mTOR signaling, extending healthspan through multi-system metabolic modulation. <a href="https://www.science.org/content/blog-post/glp-1-drugs-aging">science.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Social Network Topology</title>
    <link href="https://gregor.fyi/2026/08/12/social-network-topology/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/08/12/social-network-topology/</id>
    <published>2026-08-12T12:00:00Z</published>
    <updated>2026-08-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Sociological analysis of social network structure and Dunbar's number: weak ties provide diverse information, career optionality, and intellectual cross-pollination, while dense strong-tie clusters provide the psychological resilience and mutual aid necessary during acute crises. <a href="https://nautil.us/is-it-better-to-have-a-lot-of-casual-friends-or-a-few-close-ones-1283691">nautil.us</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Targeted Covalent Inhibitors</title>
    <link href="https://gregor.fyi/2026/08/08/targeted-covalent-inhibitors/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/08/08/targeted-covalent-inhibitors/</id>
    <published>2026-08-08T12:00:00Z</published>
    <updated>2026-08-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Latent sulfur-fluoride exchange (SuFEx) click chemistry and mild electrophiles bind non-catalytic amino acid residues with picomolar affinity, enabling targeted covalent inhibition of previously intractable protein surfaces without off-target proteomic toxicity. <a href="https://www.science.org/content/blog-post/target-practice-molecular-scale">science.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>House of Lords Sortition</title>
    <link href="https://gregor.fyi/2026/08/04/house-of-lords-sortition/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/08/04/house-of-lords-sortition/</id>
    <published>2026-08-04T12:00:00Z</published>
    <updated>2026-08-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>An institutional design proposal for bicameral constitutional reform: replacing appointed or hereditary political aristocracies with a sortition-selected citizen senate, creating an institutional check that deliberates without short-term electoral re-election incentives. <a href="https://marginalrevolution.com/marginalrevolution/2026/08/towards-a-new-house-of-lords.html?utm_source=rss&utm_medium=rss&utm_campaign=towards-a-new-house-of-lords">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Regional Chinese Noodle Mapping</title>
    <link href="https://gregor.fyi/2026/07/04/regional-chinese-noodle-mapping/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/07/04/regional-chinese-noodle-mapping/</id>
    <published>2026-07-04T12:00:00Z</published>
    <updated>2026-07-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Robert Sietsema documents regional noodle traditions across Flushing and Sunset Park, analyzing differences in gluten elasticity, alkaline water treatment, and broth emulsion techniques across Shaanxi biang biang, Lanzhou pulled noodles, and Wuhan hot dry noodles. <a href="https://robertsietsema.substack.com/p/where-to-find-the-regional-noodles">robertsietsema.substack.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>InSAR Coastal Subsidence Calibration</title>
    <link href="https://gregor.fyi/2026/06/12/insar-coastal-subsidence-calibration/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/06/12/insar-coastal-subsidence-calibration/</id>
    <published>2026-06-12T12:00:00Z</published>
    <updated>2026-06-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Geodesists re-evaluated interferometric synthetic aperture radar (InSAR) coastal subsidence maps, finding that localized groundwater pumping, building weight, and vegetation moisture variations cause satellite radars to overestimate long-term relative sea-level rise by up to 50%, mandating ground-based GPS validation. <a href="https://www.science.org/content/article/satellite-maps-sinking-coastlines-come-under-scrutiny">science.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>SRAM Infrared Remanence</title>
    <link href="https://gregor.fyi/2026/06/08/sram-infrared-remanence/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/06/08/sram-infrared-remanence/</id>
    <published>2026-06-08T12:00:00Z</published>
    <updated>2026-06-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Hardware hacker bunnie Huang demonstrates that infrared backside silicon imaging can read unpowered SRAM cell states through physical dopant charge remanence. The attack bypasses standard software memory wipes, requiring cryptographic hardware to implement active charge-neutralizing circuits before power-down. <a href="https://www.bunniestudios.com/blog/2026/on-reading-srams-in-ir-images-and-establishing-bounds-on-trust/">bunniestudios.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Simulated Annealing in Software</title>
    <link href="https://gregor.fyi/2026/06/04/simulated-annealing-in-software/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/06/04/simulated-annealing-in-software/</id>
    <published>2026-06-04T12:00:00Z</published>
    <updated>2026-06-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Avery Pennarun models software engineering decisions and organizational technical debt as simulated annealing: systems require occasional high-temperature perturbations (major refactors, breaking API shifts) to escape local optima, whereas excessive procedural cooling freezes companies into uncompetitive legacy codebases. <a href="https://apenwarr.ca/log/20260531">apenwarr.ca</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Automated Hypothesis Generation</title>
    <link href="https://gregor.fyi/2026/05/16/automated-hypothesis-generation/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/05/16/automated-hypothesis-generation/</id>
    <published>2026-05-16T12:00:00Z</published>
    <updated>2026-05-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Autonomous scientific systems like Google DeepMind's Co-Scientist generate hypotheses and design wet-lab execution protocols, but remain fundamentally throttled by wet-lab robotic execution limits and pervasive negative publication bias in training corpora. <a href="https://www.science.org/content/blog-post/evaluating-co-scientist-new-ai-science-system">science.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Blood-Brain Barrier Statin Lipophilicity</title>
    <link href="https://gregor.fyi/2026/05/12/blood-brain-barrier-statin-lipophilicity/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/05/12/blood-brain-barrier-statin-lipophilicity/</id>
    <published>2026-05-12T12:00:00Z</published>
    <updated>2026-05-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>A pharmacological and neurological investigation resolving the debate over statins and cognitive decline: while the brain requires abundant cholesterol for myelin sheaths, central nervous system cholesterol is synthesized locally by astrocytes. Because hydrophilic statins (rosuvastatin, pravastatin) cannot cross the blood-brain barrier, they lower systemic vascular risk without depleting cerebral cholesterol. <a href="https://www.cremieux.xyz/p/why-dont-statins-cause-dementia">cremieux.xyz</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Predictive Model Drift</title>
    <link href="https://gregor.fyi/2026/05/08/predictive-model-drift/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/05/08/predictive-model-drift/</id>
    <published>2026-05-08T12:00:00Z</published>
    <updated>2026-05-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Foundation model evaluations suffer from acute structural contamination: synthetic data feedback loops, benchmark memorization, and preference tuning produce brittle models that ace public benchmarks while failing on out-of-distribution reasoning. <a href="https://www.astralcodexten.com/p/nostalgebraists-hydrogen-jukeboxes">astralcodexten.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Autonomous Scientific Synthesis</title>
    <link href="https://gregor.fyi/2026/05/04/autonomous-scientific-synthesis/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/05/04/autonomous-scientific-synthesis/</id>
    <published>2026-05-04T12:00:00Z</published>
    <updated>2026-05-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Autonomous AI research agents capable of interrogating raw databases, running live replications, and generating interactive models threaten to obsolete the 10-page static PDF paper in favor of executable, queryable research repositories. <a href="https://marginalrevolution.com/marginalrevolution/2026/05/will-ai-kill-the-research-paper.html?utm_source=rss&utm_medium=rss&utm_campaign=will-ai-kill-the-research-paper">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Carboniferous Insect Gigantism</title>
    <link href="https://gregor.fyi/2026/04/08/carboniferous-insect-gigantism/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/04/08/carboniferous-insect-gigantism/</id>
    <published>2026-04-08T12:00:00Z</published>
    <updated>2026-04-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Paleobiologists explain why giant Carboniferous insects (such as 2.5-foot Meganeura dragonflies) disappeared: atmospheric oxygen levels peaked at 35% during the Carboniferous, allowing passive tracheal diffusion to oxygenate massive bodies. When oxygen levels crashed in the Permian and predatory birds subsequently evolved, tracheal diffusion permanently constrained insect body size. <a href="https://nautil.us/what-happened-to-the-ancient-bug-giants-of-300-million-years-ago-1279562">nautil.us</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Macroeconomic AI Elasticities</title>
    <link href="https://gregor.fyi/2026/04/04/macroeconomic-ai-elasticities/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/04/04/macroeconomic-ai-elasticities/</id>
    <published>2026-04-04T12:00:00Z</published>
    <updated>2026-04-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Comparative surveys of macroeconomists versus AI researchers reveal a fundamental divergence on long-term growth: economists project modest 1–2% annual TFP gains constrained by Baumol's cost disease and physical capital, whereas computer scientists forecast transformative double-digit GDP acceleration. <a href="https://marginalrevolution.com/marginalrevolution/2026/04/economists-on-ai-and-economic-growth-and-employment.html?utm_source=rss&utm_medium=rss&utm_campaign=economists-on-ai-and-economic-growth-and-employment">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Software Review Latency Compounding</title>
    <link href="https://gregor.fyi/2026/03/16/software-review-latency-compounding/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/03/16/software-review-latency-compounding/</id>
    <published>2026-03-16T12:00:00Z</published>
    <updated>2026-03-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Avery Pennarun analyzes software development velocity, showing that every additional required review step introduces an exponential 10x latency penalty. In large engineering organizations, asynchronous pull-request queues, branch integration delays, and multi-team consensus meetings dominate developer time, proving that single-piece continuous delivery outperforms multi-tiered review boards. <a href="https://apenwarr.ca/log/20260316">apenwarr.ca</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Jevons Rebound in Compute</title>
    <link href="https://gregor.fyi/2026/03/12/jevons-rebound-in-compute/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/03/12/jevons-rebound-in-compute/</id>
    <published>2026-03-12T12:00:00Z</published>
    <updated>2026-03-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>An economic analysis of Jevons' Paradox applied to artificial intelligence hardware: historic efficiency gains in GPU compute per watt (FLOPs/watt) do not reduce aggregate datacenter energy demand; instead, lowering the marginal cost of compute triggers exponential demand increases for agentic inference and synthetic data generation. <a href="https://snippet.finance/energy-efficiency/">snippet.finance</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Danish Mortgage Balance Principle</title>
    <link href="https://gregor.fyi/2026/03/08/danish-mortgage-balance-principle/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/03/08/danish-mortgage-balance-principle/</id>
    <published>2026-03-08T12:00:00Z</published>
    <updated>2026-03-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Denmark’s 'balance principle' mortgage system eliminates the housing lock-in penalty: when interest rates rise, homeowners can buy back their mortgage debt in the open market at prevailing discounted prices, preserving labor mobility. <a href="https://marginalrevolution.com/marginalrevolution/2026/03/a-danish-fix-for-u-s-mortgage-lock-in.html?utm_source=rss&utm_medium=rss&utm_campaign=a-danish-fix-for-u-s-mortgage-lock-in">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Jovian Lightning Energetics</title>
    <link href="https://gregor.fyi/2026/03/04/jovian-lightning-energetics/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/03/04/jovian-lightning-energetics/</id>
    <published>2026-03-04T12:00:00Z</published>
    <updated>2026-03-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>NASA's Juno spacecraft mapped high-energy atmospheric discharges in Jupiter's upper atmosphere, revealing that Jovian 'shallow lightning' discharges in ammonia-water clouds with energetic yields exceeding hundreds of megatons—orders of magnitude more violent than terrestrial superbolts. <a href="https://www.science.org/content/article/jupiter-s-weather-forecast-cloudy-chance-nukes">science.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Vertical Energy-Compute Scaling</title>
    <link href="https://gregor.fyi/2026/02/20/vertical-energy-compute-scaling/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/02/20/vertical-energy-compute-scaling/</id>
    <published>2026-02-20T12:00:00Z</published>
    <updated>2026-02-20T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Analyzing the long-term energy wall in terrestrial AI datacenters: gigawatt-scale frontier models will face severe electrical grid interconnection bottlenecks, favoring vertically integrated entities that co-locate generation, dedicated battery storage, and eventual orbital photovoltaic compute nodes. <a href="https://www.nextbigfuture.com/2026/02/ai-winner-will-scale-ai-energy-and-compute-on-earth-and-in-space-why-xai-spacex-and-tesla-win.html">nextbigfuture.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Clinical Biological Baselines</title>
    <link href="https://gregor.fyi/2026/02/16/clinical-biological-baselines/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/02/16/clinical-biological-baselines/</id>
    <published>2026-02-16T12:00:00Z</published>
    <updated>2026-02-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>An analysis of biological baseline drift: environmental changes, sedentary lifestyles, and microplastic exposures have altered baseline human endocrine levels (including declining testosterone and advancing puberty onset), complicating medical diagnoses that rely on historical 20th-century 'normal' reference ranges. <a href="https://www.asimov.press/p/baseline-drift">asimov.press</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Tokyo Neapolitan Fermentation</title>
    <link href="https://gregor.fyi/2026/02/12/tokyo-neapolitan-fermentation/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/02/12/tokyo-neapolitan-fermentation/</id>
    <published>2026-02-12T12:00:00Z</published>
    <updated>2026-02-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>An analysis of Tokyo-style Neapolitan pizza craft: pizzaiolos achieve superior crust texture through 48-hour cold fermentation, extreme 500°C Japanese cedar wood firing, and minimalist salt-and-oregano balancing, elevating Neapolitan pizza beyond its traditional Italian origins. <a href="http://www.grubstreet.com/article/seirinkan-tokyo-pizza-popup-nyc.html?utm_source=rss&utm_medium=social_acct&utm_campaign=feed-part">grubstreet.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Open-Source Satellite Mortuary Tracking</title>
    <link href="https://gregor.fyi/2026/02/08/open-source-satellite-mortuary-tracking/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/02/08/open-source-satellite-mortuary-tracking/</id>
    <published>2026-02-08T12:00:00Z</published>
    <updated>2026-02-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>An investigative report detailing how Russian families use updated commercial satellite imagery on Google Maps and Yandex to locate newly dug mass graves and military cemeteries near Rostov-on-Don, turning public geospatial infrastructure into open-source casualty verification networks. <a href="https://www.newyorker.com/news/the-lede/the-russians-turning-to-google-maps-in-search-of-missing-soldiers">newyorker.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Cognitive Variance Asymmetries</title>
    <link href="https://gregor.fyi/2026/02/04/cognitive-variance-asymmetries/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/02/04/cognitive-variance-asymmetries/</id>
    <published>2026-02-04T12:00:00Z</published>
    <updated>2026-02-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>A psychometric and quantitative genetic analysis of sex differences in cognitive ability distributions. While average male and female general intelligence (g) scores are indistinguishable, males consistently exhibit greater variance across mathematical and spatial subtests, resulting in asymmetric representation at the extreme tails of the distribution. <a href="https://www.cremieux.xyz/p/sex-differences-in-intelligence">cremieux.xyz</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Navier-Stokes Finite-Time Singularity</title>
    <link href="https://gregor.fyi/2026/01/12/navier-stokes-finite-time-singularity/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/01/12/navier-stokes-finite-time-singularity/</id>
    <published>2026-01-12T12:00:00Z</published>
    <updated>2026-01-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Mathematicians using physics-informed neural networks discovered potential finite-time singularities (blowups) in the 3D Euler and Navier-Stokes fluid equations. By guiding numerical solvers to self-similar coordinate collapses, the AI identified initial boundary conditions where vorticity concentrates infinitely, bringing researchers closer to resolving a Millennium Prize problem. <a href="https://www.quantamagazine.org/using-ai-mathematicians-find-hidden-glitches-in-fluid-equations-20260109/">quantamagazine.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Headless Agent IDEs</title>
    <link href="https://gregor.fyi/2026/01/08/headless-agent-ides/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/01/08/headless-agent-ides/</id>
    <published>2026-01-08T12:00:00Z</published>
    <updated>2026-01-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Steve Yegge outlines the architectural obsolescence of traditional graphical IDEs (VS Code, IntelliJ) in the era of autonomous coding agents. Software development is migrating toward headless terminal-driven agent runtimes where agents write, test, debug, and commit code continuously in the background, rendering human line-by-line editing obsolete. <a href="https://steve-yegge.medium.com/welcome-to-gas-town-4f25ee16dd04?source=rss-c1ec701babb7------2">steve-yegge.medium.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Lunar Property Rights</title>
    <link href="https://gregor.fyi/2026/01/04/lunar-property-rights/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2026/01/04/lunar-property-rights/</id>
    <published>2026-01-04T12:00:00Z</published>
    <updated>2026-01-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Outer Space Treaty prohibitions against sovereign territorial appropriation create acute legal ambiguity: absent formal property rights, first-mover mining operations risk establishing de facto exclusionary safety zones around lunar ice deposits unless bilateral market frameworks are codified. <a href="https://www.astralcodexten.com/p/you-have-only-x-years-to-escape-permanent">astralcodexten.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Neuroinflammation Incretins</title>
    <link href="https://gregor.fyi/2025/12/08/neuroinflammation-incretins/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/12/08/neuroinflammation-incretins/</id>
    <published>2025-12-08T12:00:00Z</published>
    <updated>2025-12-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Phase III clinical trials of GLP-1 receptor agonists in early Alzheimer's disease confirm substantial reductions in microglial neuroinflammation and neurofibrillary tangle progression despite modest primary cognitive score deltas, establishing neuroprotective metabolic activity in the brain. <a href="https://www.science.org/content/blog-post/another-glp-1-alzheimer-s-trial">science.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Empirical Learning Curve Limits</title>
    <link href="https://gregor.fyi/2025/12/04/empirical-learning-curve-limits/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/12/04/empirical-learning-curve-limits/</id>
    <published>2025-12-04T12:00:00Z</published>
    <updated>2025-12-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Brian Potter evaluates Wright’s Law and empirical learning curves across industries: while manufacturing sectors (solar PV, semiconductors, aircraft) consistently exhibit 15–25% cost reductions per doubling of cumulative production, construction and nuclear power experience negative learning curves due to bespoke on-site fabrication and shifting regulatory baselines. <a href="https://www.construction-physics.com/p/how-accurate-are-learning-curves">construction-physics.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>National Capital Accounting</title>
    <link href="https://gregor.fyi/2025/11/16/national-capital-accounting/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/11/16/national-capital-accounting/</id>
    <published>2025-11-16T12:00:00Z</published>
    <updated>2025-11-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Macroeconomists argue for replacing gross domestic product (GDP) with comprehensive wealth accounting: national economic metrics must measure capital stock depletion, environmental degradation, and human cognitive capital depreciation, rather than treating defensive disaster expenditures as positive economic growth. <a href="https://www.nature.com/articles/d41586-025-03721-1">nature.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Commercial Aircraft Cycle Times</title>
    <link href="https://gregor.fyi/2025/11/12/commercial-aircraft-cycle-times/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/11/12/commercial-aircraft-cycle-times/</id>
    <published>2025-11-12T12:00:00Z</published>
    <updated>2025-11-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>An economic analysis of commercial aerospace manufacturing, examining why clean-sheet commercial aircraft development cycles have lengthened from 4 years in the 1950s to over 15 years today due to regulatory certification bloat, globalized supply-chain fragmentation, and legacy airframe risk aversion. <a href="https://jordanwtaylor2.substack.com/p/the-aerospace-crystal-ball">jordanwtaylor2.substack.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Pop-Up Micro-Bakery Economics</title>
    <link href="https://gregor.fyi/2025/11/08/pop-up-micro-bakery-economics/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/11/08/pop-up-micro-bakery-economics/</id>
    <published>2025-11-08T12:00:00Z</published>
    <updated>2025-11-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>An analysis of the hyper-local micro-bakery pop-up phenomenon in Fort Greene, Brooklyn: pastry chefs bypass long-term commercial lease commitments by running shared-kitchen weekend pop-ups, leveraging social media queues to de-risk retail food entrepreneurship. <a href="http://www.grubstreet.com/article/laurel-bakery-amandas-good-morning-cafe-fort-greene-bakeries.html?utm_source=rss&utm_medium=social_acct&utm_campaign=feed-part">grubstreet.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Datacenter Baseload Energy</title>
    <link href="https://gregor.fyi/2025/11/04/datacenter-baseload-energy/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/11/04/datacenter-baseload-energy/</id>
    <published>2025-11-04T12:00:00Z</published>
    <updated>2025-11-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Gigawatt-scale electrical generation and datacenter thermal dissipation have superseded algorithmic theory as the primary pacing constraints for frontier AI, compelling direct integration with advanced nuclear and geothermal baseload infrastructure. <a href="https://marginalrevolution.com/marginalrevolution/2025/11/my-excellent-conversation-with-sam-altman.html">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Compute Overhang Asymmetries</title>
    <link href="https://gregor.fyi/2025/10/20/compute-overhang-asymmetries/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/10/20/compute-overhang-asymmetries/</id>
    <published>2025-10-20T12:00:00Z</published>
    <updated>2025-10-20T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>The concentrated geographic distribution of high-end AI compute clusters mirrors nuclear centrifuge facilities, creating aggressive international supply chain surveillance incentives as compute sovereignty emerges as a primary pillar of national defense. <a href="https://marginalrevolution.com/marginalrevolution/2025/10/jack-clark-on-ai.html?utm_source=rss&utm_medium=rss&utm_campaign=jack-clark-on-ai">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Transformers Out-of-Distribution Limits</title>
    <link href="https://gregor.fyi/2025/10/16/transformers-out-of-distribution-limits/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/10/16/transformers-out-of-distribution-limits/</id>
    <published>2025-10-16T12:00:00Z</published>
    <updated>2025-10-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Sabine Hossenfelder identifies three fundamental architectural limitations of current autoregressive transformers: reliance on static training distributions that prevents true novel inductive generalization, inability to verify factual ground truth without external symbolic engines, and quadratic scaling energy consumption on long-context attention. <a href="http://backreaction.blogspot.com/2025/10/current-ai-models-have-3-unfixable.html">backreaction.blogspot.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Hyperspectral Aerial Metagenomics</title>
    <link href="https://gregor.fyi/2025/10/12/hyperspectral-aerial-metagenomics/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/10/12/hyperspectral-aerial-metagenomics/</id>
    <published>2025-10-12T12:00:00Z</published>
    <updated>2025-10-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Aerial and satellite hyperspectral imaging detects plant microbiome shifts and pathogen colonization in shortwave infrared reflectance signatures days before visible leaf wilting, enabling predictive agricultural intervention. <a href="https://www.asimov.press/p/hyperspectral">asimov.press</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Su Filindeu Preservation</title>
    <link href="https://gregor.fyi/2025/10/08/su-filindeu-preservation/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/10/08/su-filindeu-preservation/</id>
    <published>2025-10-08T12:00:00Z</published>
    <updated>2025-10-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>The preservation of Su Filindeu ('the threads of God'), an ancient Sardinian pasta made by repeatedly pulling and folding semolina dough into 256 gossamer-thin parallel strands: requiring an extraordinary feel for ambient humidity, gluten elasticity, and salted-water hydration, it remains one of the world's most physically demanding artisanal craft traditions. <a href="https://feedly.com/i/entry/zAQGqkO81irNAGq27QJzmIMEQGWmAp0js0Jq1YcCss8=_199f44cfac9:127e9c:fe5bf740">feedly.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Fly-By-Wire Retrofits</title>
    <link href="https://gregor.fyi/2025/10/04/fly-by-wire-retrofits/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/10/04/fly-by-wire-retrofits/</id>
    <published>2025-10-04T12:00:00Z</published>
    <updated>2025-10-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Sikorsky and DARPA successfully converted a standard UH-60 Black Hawk helicopter into a fully autonomous uncrewed aircraft in 10 months using the MATRIX autonomy kit. The retrofitted fly-by-wire system executes low-altitude tactical resupply and casualty evacuations in contested environments without human intervention. <a href="https://www.nextbigfuture.com/2025/10/black-hawk-converted-into-an-unmanned-drone-in-10-months.html">nextbigfuture.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Life In Our Phage World: Viable AI-mutated phages</title>
    <link href="https://gregor.fyi/2020/01/05/life-in-our-phage-world/#2025-09-18" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2020/01/05/life-in-our-phage-world/#2025-09-18</id>
    <published>2025-09-18T12:00:00Z</published>
    <updated>2025-09-18T12:00:00Z</updated>
    <thr:in-reply-to ref="https://gregor.fyi/2020/01/05/life-in-our-phage-world/" href="https://gregor.fyi/2020/01/05/life-in-our-phage-world/" type="text/html"/>
    <content type="html"><![CDATA[<p class="update-context"><em>Update to <a href="https://gregor.fyi/2020/01/05/life-in-our-phage-world/">Life In Our Phage World</a>:</em></p>
<blockquote>the researchers mixed all 16 AI-generated phages with ΦX174 and then threw them into a tube with E. coli cells. Because the phages were forced to compete for the same host cells, the variants that reproduced fastest would dominate. By sequencing the phages over time, the researchers could track which phages were gaining ground and which were falling behind. Several of the AI phages consistently outperformed wild ΦX174, with one variant (called Evo-Φ69) increasing to 65x its starting level.

Ultimately, these <a href="https://web.archive.org/web/20250918194741/https://press.asimov.com/articles/ai-phages">16 AI-generated phages</a> were not only viable; in many cases, they were more infectious than wildtype ΦX174 despite carrying major genome alterations that a human would be unlikely to rationally design.</blockquote>]]></content>
  </entry>
  <entry>
    <title>Micro-Roastery Real Estate</title>
    <link href="https://gregor.fyi/2025/09/16/micro-roastery-real-estate/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/09/16/micro-roastery-real-estate/</id>
    <published>2025-09-16T12:00:00Z</published>
    <updated>2025-09-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>An examination of specialized micro-roasteries and bespoke coffee boutiques taking over high-density Manhattan retail spaces, analyzing how precision temperature-controlled single-origin offerings sustain high profit margins despite soaring urban commercial rents. <a href="http://www.grubstreet.com/article/step-into-the-brewtique.html?utm_source=rss&utm_medium=social_acct&utm_campaign=feed-part">grubstreet.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Wow! Signal and Magnetar Masers</title>
    <link href="https://gregor.fyi/2025/09/12/wow-signal-magnetar-masers/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/09/12/wow-signal-magnetar-masers/</id>
    <published>2025-09-12T12:00:00Z</published>
    <updated>2025-09-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Re-evaluating the 1977 Ohio State Wow! signal against modern astrophysical surveys: astronomical data suggests the narrow-band 1420 MHz burst could have originated from a rare hydrogen cloud maser flare stimulated by a distant soft gamma repeater or magnetar outburst rather than artificial extraterrestrial transmission. <a href="https://avi-loeb.medium.com/was-the-wow-signal-emitted-from-3i-atlas-d18d4f0d1f1e">avi-loeb.medium.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>0.001% Mathlib: Gauss</title>
    <link href="https://gregor.fyi/2021/07/28/0001-mathlib/#2025-09-11" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2021/07/28/0001-mathlib/#2025-09-11</id>
    <published>2025-09-11T12:00:00Z</published>
    <updated>2025-09-11T12:00:00Z</updated>
    <thr:in-reply-to ref="https://gregor.fyi/2021/07/28/0001-mathlib/" href="https://gregor.fyi/2021/07/28/0001-mathlib/" type="text/html"/>
    <content type="html"><![CDATA[<p class="update-context"><em>Update to <a href="https://gregor.fyi/2021/07/28/0001-mathlib/">0.001% Mathlib</a>:</em></p>
<blockquote>Using Gauss <a href="https://web.archive.org/web/20250911214133/https://www.math.inc/gauss">we produced ~25K lines of Lean code</a>, comprising 1K theorems and definitions. Formal proofs of this scale have historically been major milestones, often the culmination of multi-year efforts. The largest singular formalization projects in history — career-defining efforts, which can span more than a decade — are only an order of magnitude larger at up to 500K LOC. Lean’s standard mathematical library, Mathlib, is 1 OOM beyond that, at 2M LOC, comprising 350K Lean theorems and definitions, and developed by 600 human contributors over 8 years. With further algorithmic improvements, we aim to increase the sum total of formal code by 2-3 OOM in the coming 12 months. This will serve as the training ground for a <a href="https://web.archive.org/web/20250911214133mp_/https://www.math.inc/vision">new paradigm</a> — verified superintelligence and the machine polymaths that will power it.</blockquote>]]></content>
  </entry>
  <entry>
    <title>Modular Diner Preservation</title>
    <link href="https://gregor.fyi/2025/09/08/modular-diner-preservation/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/09/08/modular-diner-preservation/</id>
    <published>2025-09-08T12:00:00Z</published>
    <updated>2025-09-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Food historian Robert Sietsema documents the architecture and cultural preservation of prefabricated mid-century diners in New York City. Manufactured in New Jersey and moved by flatbed truck, these streamlined stainless steel diners embody mid-century modular industrial design and immigrant culinary integration. <a href="https://robertsietsema.substack.com/p/my-favorite-nyc-diners-right-now">robertsietsema.substack.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Rogue Wave Physics</title>
    <link href="https://gregor.fyi/2025/09/04/rogue-wave-physics/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/09/04/rogue-wave-physics/</id>
    <published>2025-09-04T12:00:00Z</published>
    <updated>2025-09-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Oceanographers and non-linear physicists confirmed that oceanic rogue waves form through modulational instability—the Benjamin-Feir instability—where non-linear interactions cause small ocean wave trains to spontaneously borrow energy from surrounding waves, concentrating amplitude into a colossal single wave in seconds without requiring bathymetric seabed triggers. <a href="https://nautil.us/rogue-wave-mystery-solved-1236928/">nautil.us</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Sterile Microfluidic Lyophilization</title>
    <link href="https://gregor.fyi/2025/08/12/sterile-microfluidic-lyophilization/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/08/12/sterile-microfluidic-lyophilization/</id>
    <published>2025-08-12T12:00:00Z</published>
    <updated>2025-08-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Inventor Dean Kamen demonstrated a breakthrough continuous automated manufacturing platform for shelf-stable room-temperature vaccines. By using precision acoustic droplet ejectors and flash lyophilization, the machine produces room-temperature stable, dry-powder vaccines at cents per dose, completely bypassing the cold-chain bottleneck in developing nations. <a href="https://www.flickr.com/photos/jurvetson/54724916801">flickr.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Indian Civil Service Rent-Seeking</title>
    <link href="https://gregor.fyi/2025/08/08/indian-civil-service-rent-seeking/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/08/08/indian-civil-service-rent-seeking/</id>
    <published>2025-08-08T12:00:00Z</published>
    <updated>2025-08-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Millions of India's top university graduates spend their peak productive years memorizing trivia for low-odds civil service exams in coaching hubs like Kota, illustrating massive rent-seeking human capital dissipation generated by state-dominated economies. <a href="https://marginalrevolution.com/marginalrevolution/2025/08/the-tragedy-of-indias-government-job-prep-towns.html?utm_source=rss&utm_medium=rss&utm_campaign=the-tragedy-of-indias-government-job-prep-towns">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Busy Beaver 5 Decidability</title>
    <link href="https://gregor.fyi/2025/08/04/busy-beaver-5-decidability/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/08/04/busy-beaver-5-decidability/</id>
    <published>2025-08-04T12:00:00Z</published>
    <updated>2025-08-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Theoretical computer scientists and a collaborative team of mathematicians formally resolved BB(5)—the maximum number of steps a 5-state Turing machine can execute before halting (exactly 47,176,870 steps). The formal Coq proof verified the behavior of billions of candidate machines, marking the boundary where computer program verification remains computable. <a href="https://www.quantamagazine.org/busy-beaver-hunters-reach-numbers-that-overwhelm-ordinary-math-20250822/">quantamagazine.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>AI Physical Logistics</title>
    <link href="https://gregor.fyi/2025/07/16/ai-physical-logistics/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/07/16/ai-physical-logistics/</id>
    <published>2025-07-16T12:00:00Z</published>
    <updated>2025-07-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Austin Vernon analyzes how multimodal AI vision models and automated routing algorithms impact physical transportation infrastructure. Rather than autonomous vehicles eliminating human drivers overnight, AI's biggest productivity gains emerge from optimizing backhaul freight matching, dynamic yard management, and automated warehousing throughput. <a href="https://austinvernon.site/blog/ailogistics.html">austinvernon.site</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Clonal Hematopoiesis in Atherosclerosis</title>
    <link href="https://gregor.fyi/2025/07/12/clonal-hematopoiesis-atherosclerosis/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/07/12/clonal-hematopoiesis-atherosclerosis/</id>
    <published>2025-07-12T12:00:00Z</published>
    <updated>2025-07-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Somatic mutations in hematopoietic stem cells driving clonal hematopoiesis of indeterminate potential (CHIP) double cardiovascular disease risk independent of cholesterol: mutated circulating macrophages hyper-secrete inflammatory cytokines, accelerating arterial plaque progression. <a href="https://www.science.org/content/blog-post/new-cause-of-atherosclerosis">science.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Diffusion Compositionality Calibration</title>
    <link href="https://gregor.fyi/2025/07/08/diffusion-compositionality-calibration/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/07/08/diffusion-compositionality-calibration/</id>
    <published>2025-07-08T12:00:00Z</published>
    <updated>2025-07-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Modern diffusion and multimodal autoregressive architectures reliably parse and render complex spatial-relational prompts, confirming that generative vision systems acquire true relational compositionality rather than superficial pixel blending. <a href="https://www.astralcodexten.com/p/now-i-really-won-that-ai-bet">astralcodexten.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Neanderthal Culinary Traditions</title>
    <link href="https://gregor.fyi/2025/07/04/neanderthal-culinary-traditions/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/07/04/neanderthal-culinary-traditions/</id>
    <published>2025-07-04T12:00:00Z</published>
    <updated>2025-07-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Microscopic and chemical residue analysis on charred food remains from Shanidar Cave in Iraq showed that Neanderthals prepared complex, multi-ingredient cooked meals combining crushed wild mustard seeds, wild legumes, and roasted plant tubers. The intentional blending of bitter herbs for flavor demonstrates that culinary culture predates Homo sapiens. <a href="https://nautil.us/neanderthals-might-have-shared-family-recipes-1224982/">nautil.us</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Frontier AI Threat Intelligence</title>
    <link href="https://gregor.fyi/2025/06/16/frontier-ai-threat-intelligence/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/06/16/frontier-ai-threat-intelligence/</id>
    <published>2025-06-16T12:00:00Z</published>
    <updated>2025-06-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Analysis of state-sponsored influence campaigns attempting to leverage frontier models for automated spear-phishing, polymorphic malware generation, and synthetic social astroturfing: operational telemetry demonstrates that multi-turn model guardrails consistently force attackers into high-latency manual workarounds. <a href="https://openai.com/global-affairs/disrupting-malicious-uses-of-ai-june-2025">openai.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Autonomous Urban Redesign</title>
    <link href="https://gregor.fyi/2025/06/12/autonomous-urban-redesign/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/06/12/autonomous-urban-redesign/</id>
    <published>2025-06-12T12:00:00Z</published>
    <updated>2025-06-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Urban planners analyze algorithmic and computational land reallocation: using automated cadastral re-parcellation and land-readjustment protocols, growing cities can redraw messy, fragmented property boundaries to install public transit corridors and utilities without protracted eminent domain litigation. <a href="https://www.worksinprogress.news/p/how-to-redraw-a-city">worksinprogress.news</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Pleistocene Siberian Dispersal</title>
    <link href="https://gregor.fyi/2025/06/08/pleistocene-siberian-dispersal/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/06/08/pleistocene-siberian-dispersal/</id>
    <published>2025-06-08T12:00:00Z</published>
    <updated>2025-06-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Ancient DNA extracted from Denisova and Chagyrskaya Caves in the Altai Mountains revealed that Neanderthals made multiple migrations spanning over 2,000 miles across the Eurasian steppe during warm interglacial windows, adapting their lithic tool industries to hunt steppe bison and horses in harsh subarctic environments. <a href="https://nautil.us/how-neanderthals-got-to-siberia-1219065/">nautil.us</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Myostatin Inhibition with Incretins</title>
    <link href="https://gregor.fyi/2025/06/04/myostatin-inhibition-with-incretins/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/06/04/myostatin-inhibition-with-incretins/</id>
    <published>2025-06-04T12:00:00Z</published>
    <updated>2025-06-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Biotech clinical trials demonstrated that pairing GLP-1 receptor agonists with monoclonal antibodies inhibiting myostatin (bimagrumab/trevogrumab) produces dramatic body composition shifts: patients lost 25% of body fat while simultaneously gaining lean skeletal muscle mass, overcoming the primary sarcopenic side-effect of modern anti-obesity therapies. <a href="https://www.nextbigfuture.com/2025/06/finally-miracle-combo-weight-loss-and-muscle-growth-without-steroids.html">nextbigfuture.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Skyscraper Height Economics</title>
    <link href="https://gregor.fyi/2025/05/16/skyscraper-height-economics/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/05/16/skyscraper-height-economics/</id>
    <published>2025-05-16T12:00:00Z</published>
    <updated>2025-05-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Brian Potter examines the economic limits of supertall skyscrapers: while modern structural engineering can build kilometer-high towers, commercial viability peaks at 60–80 stories. Beyond this height, the exponential volume consumed by elevator shafts, structural dampening cores, and wind-load bracing destroys rentable floor area efficiency. <a href="https://www.worksinprogress.news/p/why-skyscrapers-are-so-short">worksinprogress.news</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Extremophile Appliance Biofilms</title>
    <link href="https://gregor.fyi/2025/05/12/extremophile-appliance-biofilms/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/05/12/extremophile-appliance-biofilms/</id>
    <published>2025-05-12T12:00:00Z</published>
    <updated>2025-05-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Microbiologists analyzing residential dishwashers identified hyper-polyextremotolerant black yeasts (Exophiala dermatitidis) thriving under cyclical heat shock, high alkalinity, and synthetic detergents. These human-engineered artificial extreme environments accelerate evolutionary selection for resilient fungal pathogens capable of colonizing immunocompromised patients. <a href="https://nautil.us/your-dishwasher-could-harbor-the-next-chonkus-1213438/">nautil.us</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Allogeneic CAR-NK Therapies</title>
    <link href="https://gregor.fyi/2025/05/08/allogeneic-car-nk-therapies/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/05/08/allogeneic-car-nk-therapies/</id>
    <published>2025-05-08T12:00:00Z</published>
    <updated>2025-05-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Clinical trials of off-the-shelf allogeneic CAR-NK (natural killer) cell therapies demonstrate durable remissions in relapsed/refractory Hodgkin’s lymphoma patients without causing graft-versus-host disease or cytokine release syndrome, establishing a scalable alternative to autologous CAR-T manufacturing. <a href="https://www.science.org/content/blog-post/new-cell-therapy-resistant-hodkins-patients">science.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Emergent Norms in Multi-Agent LLMs</title>
    <link href="https://gregor.fyi/2025/05/04/emergent-norms-multi-agent-llms/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/05/04/emergent-norms-multi-agent-llms/</id>
    <published>2025-05-04T12:00:00Z</published>
    <updated>2025-05-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Decentralized populations of LLM agents interacting in economic and coordination games spontaneously evolve shared behavioral conventions and linguistic dialects without centralized governance, demonstrating that social norms emerge naturally from repeated cooperative game-theoretic equilibria. <a href="https://www.nature.com/articles/d41586-025-01500-6">nature.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Observational Nutritional Epidemiology</title>
    <link href="https://gregor.fyi/2025/04/16/observational-nutritional-epidemiology/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/04/16/observational-nutritional-epidemiology/</id>
    <published>2025-04-16T12:00:00Z</published>
    <updated>2025-04-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>A methodological critique of observational nutritional epidemiology, showing that food frequency questionnaires produce effect sizes indistinguishable from residual socioeconomic and lifestyle confounding. The analysis warns against basing public health dietary guidelines on non-randomized observational correlations. <a href="https://www.cremieux.xyz/p/nutrition-beliefs-are-just-so-stories">cremieux.xyz</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Reciprocal Drug Approval</title>
    <link href="https://gregor.fyi/2025/04/12/reciprocal-drug-approval/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/04/12/reciprocal-drug-approval/</id>
    <published>2025-04-12T12:00:00Z</published>
    <updated>2025-04-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Unilateral reciprocal drug approval—granting automatic domestic marketing clearance to pharmaceuticals and medical devices approved by rigorous peer regulators (EMA, MHRA, PMDA)—would eliminate redundant clinical trials and terminate lethal administrative delays. <a href="https://marginalrevolution.com/marginalrevolution/2025/04/a-blueprint-for-fda-reform.html">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Microdroplet Interface Chemistry</title>
    <link href="https://gregor.fyi/2025/04/08/microdroplet-interface-chemistry/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/04/08/microdroplet-interface-chemistry/</id>
    <published>2025-04-08T12:00:00Z</published>
    <updated>2025-04-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Spontaneous electric fields reaching 10^9 V/m at the air-water interface of microdroplets accelerate chemical reactions by up to a million-fold compared to bulk solution, enabling spontaneous abiotic generation of hydrogen peroxide and organic synthesis without external catalysts or applied voltages. <a href="https://www.science.org/content/blog-post/what-s-going-water-droplets">science.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Convergent Avian Pallium</title>
    <link href="https://gregor.fyi/2025/04/04/convergent-avian-pallium/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/04/04/convergent-avian-pallium/</id>
    <published>2025-04-04T12:00:00Z</published>
    <updated>2025-04-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Comparative neuroanatomists mapped the nuclear brain architecture of corvids and parrots, discovering that advanced cognitive reasoning, causal inference, and recursive tool use evolved independently in avian pallium structures lacking the mammalian 6-layered neocortex, demonstrating that complex intelligence can arise from fundamentally different neural architectures. <a href="https://www.quantamagazine.org/intelligence-evolved-at-least-twice-in-vertebrate-animals-20250407/">quantamagazine.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Compounded Semaglutide Economics</title>
    <link href="https://gregor.fyi/2025/03/16/compounded-semaglutide-economics/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/03/16/compounded-semaglutide-economics/</id>
    <published>2025-03-16T12:00:00Z</published>
    <updated>2025-03-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>An empirical analysis of FDA drug shortage compounding regulations and active pharmaceutical ingredient (API) gray markets: compounding pharmacies exploited statutory shortage carve-outs to synthesize and distribute generic semaglutide and tirzepatide at $50/month, undermining Novo Nordisk's and Eli Lilly's $1,000/month monopoly list prices. <a href="https://www.cremieux.xyz/p/how-to-get-cheap-ozempic">cremieux.xyz</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Interspecies Hunting Mutualism</title>
    <link href="https://gregor.fyi/2025/03/12/interspecies-hunting-mutualism/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/03/12/interspecies-hunting-mutualism/</id>
    <published>2025-03-12T12:00:00Z</published>
    <updated>2025-03-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Marine behavioral ecologists documented sophisticated collaborative hunting partnerships between groupers and moray eels on coral reefs. Groupers use deliberate visual gestures to recruit eels into narrow reef crevices, actively coordinating spatial tactics across divergent evolutionary phyla to maximize predatory yield. <a href="https://nautil.us/when-fish-follow-you-1198703/">nautil.us</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Genetic Regulators of Brain Aging</title>
    <link href="https://gregor.fyi/2025/03/08/genetic-regulators-brain-aging/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/03/08/genetic-regulators-brain-aging/</id>
    <published>2025-03-08T12:00:00Z</published>
    <updated>2025-03-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Genome-wide association studies across 40,000 brain MRIs identify 64 conserved genetic loci directly modulating cerebral cortical thinning and neurovascular senescence. The loci cluster heavily around microglial autophagy and myelin lipid recycling, decoupling biological brain age from chronological age. <a href="https://www.nature.com/articles/d41586-025-00766-0">nature.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Far-UVC Pathogen Inactivation</title>
    <link href="https://gregor.fyi/2025/03/04/far-uvc-pathogen-inactivation/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/03/04/far-uvc-pathogen-inactivation/</id>
    <published>2025-03-04T12:00:00Z</published>
    <updated>2025-03-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Epidemiologists and biophysicists demonstrate that continuous 222-nanometer far-UVC light safely inactivates airborne viruses and bacteria in occupied indoor spaces without penetrating the human stratum corneum or corneal tear layer. Deploying far-UVC light fixtures offers a universal engineering solution to suppress airborne epidemic transmission in schools, hospitals, and transit. <a href="https://www.worksinprogress.news/p/flipping-the-switch-on-far-uvc">worksinprogress.news</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Mathematical Universe and Ontological Proofs</title>
    <link href="https://gregor.fyi/2025/02/20/mathematical-universe-ontological-proofs/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/02/20/mathematical-universe-ontological-proofs/</id>
    <published>2025-02-20T12:00:00Z</published>
    <updated>2025-02-20T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Scott Alexander analyzes Max Tegmark’s Level IV multiverse—where all mathematically consistent structures physically exist. If every computable universe is realized necessarily by mathematical existence alone, ontological and cosmological arguments requiring a prime mover or contingent creator collapse, as existence requires no external causal grounding. <a href="https://www.astralcodexten.com/p/tegmarks-mathematical-universe-defeats">astralcodexten.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>RNA in Neurodegeneration</title>
    <link href="https://gregor.fyi/2025/02/16/rna-in-neurodegeneration/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/02/16/rna-in-neurodegeneration/</id>
    <published>2025-02-16T12:00:00Z</published>
    <updated>2025-02-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Emerging pathology indicates that repeat expansion neurodegenerative diseases (ALS, FTD) stem from toxic RNA foci disrupting liquid-liquid phase separation rather than protein aggregation alone. <a href="https://www.science.org/content/blog-post/neurodegeneration-might-come-down-rna">science.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Episodic Event Scripts</title>
    <link href="https://gregor.fyi/2025/02/12/episodic-event-scripts/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/02/12/episodic-event-scripts/</id>
    <published>2025-02-12T12:00:00Z</published>
    <updated>2025-02-12T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Cognitive neuroscientists demonstrated that the human hippocampus compresses continuous daily life into discrete episodic memories using structured 'event scripts'. By tracking neural firing patterns during transitions between conceptual scenes, researchers proved that personal memory is organized as hierarchical semantic subroutines rather than continuous video-like recordings. <a href="https://www.quantamagazine.org/how-event-scripts-structure-our-personal-memories-20250221/">quantamagazine.org</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Epistemic Levels of AI</title>
    <link href="https://gregor.fyi/2025/02/08/epistemic-levels-of-ai/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/02/08/epistemic-levels-of-ai/</id>
    <published>2025-02-08T12:00:00Z</published>
    <updated>2025-02-08T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Frontier reasoning models function not as stochastic parrots or basic task automators, but as emergent epistemological reasoning engines capable of altering scientific hypothesis generation and institutional decision-making. <a href="https://marginalrevolution.com/marginalrevolution/2025/02/the-three-levels-of-ai-understanding.html">marginalrevolution.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Martian Fission Radiators</title>
    <link href="https://gregor.fyi/2025/02/04/martian-fission-radiators/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/02/04/martian-fission-radiators/</id>
    <published>2025-02-04T12:00:00Z</published>
    <updated>2025-02-04T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Electrical power output for Martian nuclear reactors is strictly constrained by radiative heat rejection surface area: operating closed-loop Brayton cycles at elevated rejection temperatures with lightweight post-stressed concrete radiators maximizes megawatt-scale power density in thin atmospheric conditions. <a href="https://caseyhandmer.wordpress.com/2025/02/14/maximizing-electrical-power-output-from-a-nuclear-reactor-delivered-by-starship-to-a-base-on-mars/">caseyhandmer.wordpress.com</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Allometric Scaling in Biology</title>
    <link href="https://gregor.fyi/2025/01/20/allometric-scaling-biology/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/01/20/allometric-scaling-biology/</id>
    <published>2025-01-20T12:00:00Z</published>
    <updated>2025-01-20T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>Kleiber’s law and metabolic scaling theory explain how quarter-power allometric scaling governs biological pace from unicellular microbes to blue whales: mass-specific metabolic rates fall predictably as organism size increases, constrained by the fractal geometry of internal nutrient-distribution networks. <a href="https://snippet.finance/scaling-in-biology/">snippet.finance</a></blockquote>]]></content>
  </entry>
  <entry>
    <title>Bioacoustic Transformer Decoding</title>
    <link href="https://gregor.fyi/2025/01/16/bioacoustic-transformer-decoding/" rel="alternate" type="text/html"/>
    <id>https://gregor.fyi/2025/01/16/bioacoustic-transformer-decoding/</id>
    <published>2025-01-16T12:00:00Z</published>
    <updated>2025-01-16T12:00:00Z</updated>
    <content type="html"><![CDATA[<blockquote>An evaluation of machine learning in non-human bioacoustics: applying unsupervised transformer models to sperm whale click codas and bat vocalizations has decoded combinatorial linguistic rules, phonetic alphabets, and contextual syntax, establishing a technical pipeline for interspecies communication. <a href="https://humanprogress.org/using-ai-to-talk-to-animals/">humanprogress.org</a></blockquote>]]></content>
  </entry>
</feed>