Historically, synthetic biology has heavily focused on using well understood microbes such as E. coli as the “chassis” for engineering new biological processes—which at times has been criticized as a shortcoming of the field. Plants grow to an astounding number of different sizes and shapes, feed us, clothe us, provide the majority of our materials, and are estimated to constitute ~80% of the total biomass on Earth. Despite their central role in our existence, plants have been largely ignored in synthetic biology because of the difficulty associated with engineering them.

A central goal of synthetic biology has been to improve our ability to design new genetic circuits capable of carrying out complex processes. This type of computation is not a metaphor. An active area of research has been to establish a hardware description language for cells, where engineers can describe their intended process, and compile it into a DNA sequence with the appropriate circuits. They were specifically interested in lateral root density, which quantifies the number of outgrowths branching to the side from the main descending root. A higher lateral root density enables plants to better sample their environment for water and nutrients. Being able to precisely engineer this type of trait has global implications—this type of technology may be essential for sustaining agriculture in the future, and could be used as a tool to mitigate challenges plants will face in a warming climate.

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