Sapere Aude
Month: February 2021
At their newest venture, Dhamaka, located inside Essex Market, diners won’t find butter chicken on the menu. In fact, it’s likely that a majority of restaurant goers won’t recognize most of the dishes on the menu here. For Pandya and Mazumdar, that’s an intentional choice.
yes! down with stupid butter chicken, bring out the good stuff.
The mean change in body weight from baseline to week 68 was −14.9% in the semaglutide group as compared with −2.4% with placebo, for an estimated treatment difference of −12.4% (95% confidence interval [CI], −13.4 to −11.5; P<0.001). More participants in the semaglutide group than in the placebo group achieved weight reductions of 5% or more (1047 participants [86.4%] vs. 182 [31.5%]), 10% or more (838 [69.1%] vs. 69 [12.0%]), and 15% or more (612 [50.5%] vs. 28 [4.9%]) at week 68 (P<0.001 for all 3 comparisons of odds). The change in body weight from baseline to week 68 was −15.3 kg in the semaglutide group as compared with −2.6 kg in the placebo group (estimated treatment difference, −12.7 kg; 95% CI, −13.7 to −11.7). Participants who received semaglutide had a greater improvement with respect to cardiometabolic risk factors and a greater increase in participant-reported physical functioning from baseline than those who received placebo.
this could be the first weight loss drug that actually works. if true, huge public health implications.
I think most psychiatric disorders exist on a spectrum from mostly-tradeoff to mostly-failure (what we might call “high-functioning” and “low-functioning” versions of the same phenotype).
Mostly-tradeoff ADHD looks like someone who is adventurous, likes variety, and thrives in high-stress situations, but is also bad at tolerating boring situations.
Mostly-tradeoff schizophrenia (which might be schizotypal personality disorder, or a subset of it, I’m not sure) looks like someone who is creative, attuned to interesting patterns, and charismatic, but also a bit odd and superstitious.
Mostly-tradeoff OCD (which might be obsessive-compulsive personality disorder) looks like somebody who’s responsible and perfectionist, but has trouble letting things go.
I think Cluster B personality disorders are already tradeoffs; adding failures just make them less effective ones. For example, tradeoff-antisocial-personality is a con man who uses unethical means to get ahead (and sometimes succeeds); tradeoff-plus-failure-antisocial usually ends up in prison very quickly and never gets out.
Helping Intel stay in the semiconductor manufacturing game should be among one of the highest priorities for all US-based technology companies. While TSMC is the leader in manufacturing process technology, they remain a geo-political risk should China decide to enforce its will on the region. Samsung is not far behind, but being a Korean company, again, future politics guarantee no safe bets. Having a leading semiconductor company founded and based in the US is incredibly strategic given how critical semiconductors are to our digital future. Apple may be one of the only companies that can help Intel right the ship.
Understanding energy expenditure can help scientists understand how well animals are doing and whether they are going to be able to hunt, reproduce, and survive. Wilson has used accelerometers to study all sorts of animals including sea turtles, sheep, bats, hawks, and penguins. He combines the accelerometer data with inputs from other sensors that measure temperature, magnetic force, and geolocation to understand exactly what the animal is doing and where it is. The technology allows him to track penguins as they sit on their nests, get up, waddle to the ocean, and dive in. His sensors can stay on the animals for weeks, and after he retrieves the devices, he can follow along as the penguins swim and dive and fish, all from 1000s of km away.
Buy a large thermos bottle, and fill it with either Chinese herbal tea or whiskey, as a desk-side companion. Set a reminder on your phone to drink 8 glasses of water every day, and leave your workstation every 50 minutes to get that water. Start doing 15 minutes of stretches, or planking, in the office pantry. Set the goal of becoming the person who uses the most toilet paper in the company.
These are some of the tips for how to slack off at work provided by Massage Bear. Her philosophy of “touching fish” (mō yú), synonymous with lazing around at work, has resonated with many Chinese, increasingly exhausted by society’s ever more intense rat race.
as China becomes more prosperous, bullshit jobs are growing, just like in other advanced economies. Makes me wonder whether the transition to UBI will happen faster in China if these trends accelerate, as they likely will.
Gregor J. Rothfuss 