Proteins convert from one observable shape to another in less than 1 trillionth of a second, and in molecules that are less than 1 millionth of a cm in size. These changes have been simulated by computers, but no one had ever observed how they happen. Apparently ~0.02% get trapped in a highly unlikely shape that is like a single frame in a movie. The set of these trapped residues taken together have basically allowed us to make a movie that shows how these special protein shape changes occur. And what this movie shows has real differences from what the computer simulations have predicted.”

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